2011 Fiscal Year Final Research Report
Identification and analysis of blastema-specific molecules that are targeted by immature immune system in Xenopus tadoples
| Project/Area Number |
22659080
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KUBO Takeo 東京大学, 大学院・理学系研究科, 教授 (10201469)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 動物 / 免疫系 / 再生 |
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| Research Abstract |
So far, we suggested that, in the' refractory period' of the Xenopus tadpoles, immature immune cells attack blastema cells of the amputated tails as' non-self', resulting in failure in tail regeneration, whereas, in the' regeneration period', regulatory T cells differentiate to reactivate tail regenerative ability. However, what kinds of immune cells target the blastema cells remains unclear. In the present study, we identified a novel gene that is supposed to be expressed in immune cells that invade amputated tail stumps to repress tail regenerative ability. This gene played an essential role in tadpole survival during the developmental stages. This gene will be available as a maker for auto-reactive immune cells that attack tail blastema cells.
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