2012 Fiscal Year Final Research Report
Novel Complementary Peptides Control Inflammatory Responses
| Project/Area Number |
22659081
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Nagoya City University |
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Principal Investigator |
OKADA Noriko 名古屋市立大学, 大学院・医学研究科, 教授 (20160682)
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| Co-Investigator(Kenkyū-buntansha) |
IMAI Masaki 名古屋市立大学, 大学院・医学研究科, 講師 (30440936)
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| Project Period (FY) |
2010 – 2012
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| Keywords | アナフィラトキシン C5a / エンドトキシンショック / 補体 |
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| Research Abstract |
C5a anaphylatoxin is considered to be an effective target for treatment of hyperinflammation since C5a stimulates neutrophils and endothelial cells, then generation of tumor necrosis factor alpha (TNFα) and other inflammatory cytokines. To clear how C5a induces to serious inflammatory responses, we generated C5a inhibitory peptides with an evolutionary computer program that generates complementary peptide (C-pep) sequences. We showed that a novel C5a C-peptide, AcpepA significantly improved an injury score compared to PBS control on rat model with brain ischemia and reperfusion injury.
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Research Products
(24 results)
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[Journal Article] Endothelin Receptor Antagonist Attenuates Oxidative Stress in Neonatal Sepsis Model2012
Author(s)
Goto T, Hussein MH, Kato S, Daoud GA, Kato T, Sugiura T, Kakita H, Nobata M, Kamei M, Mizuno H, Imai M, Ito T, Kato I, Suzuki S, Okada N, Togari H, Okada H
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Journal Title
Pediatric Research
Volume: 72
Pages: 600-605
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[Journal Article] Guideline for Hereditary Angioedema (HAE) 2010 by the Japanase Association for Complement Research - Secondary Publication2012
Author(s)
Horiuchi T., Ohi H., Ohsawa I., Fujita T., Matsushita M., Okada N., Seya T., Yamamoto T., Endo Y., Hatanaka M., Wakamiya N., Matsumoto M., Inoue N., Nonaka M., Kinoshita T
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Journal Title
Allegology Int
Volume: 61
Pages: 559-562
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[Journal Article] Increased levels of cytokines and high-mobility group box 1 are associated with the development of severe pneumonia, but not acute encephalopathy2011
Author(s)
Ito Y, Torii Y, Ohta R, Imai M, Hara S, Kawano Y, Matsubayashi T, Inui A, Yoshikawa T, Nishimura N, Ozaki T, Morishima T, Kimura H
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Journal Title
in 2009 H1N1 influenza-infected children. Cytokine
Volume: 56
Pages: 180-187
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[Journal Article] Endothelin receptor antagonist attenuates inflammatory response and prolongs the survival time in a neonatal sepsis model2010
Author(s)
Goto T, Hussein MH, Kato S, Daoud GA, Kato T, Sugiura T, Kakita H, Nobata M, Mizuno H, Imai M, Ito T, Kato I, Suzuki S, Okada N, Togari H, Okada H
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Journal Title
Eur J Intensive Care Med
Volume: 36(12)
Pages: 2132-2139
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[Presentation] C5a is a target to prevent peritoneal tissue damage in acute peritoneal injury in rats2012
Author(s)
Mizuno T, Mizuno M, Imai M, Suzuki Y, Kushida M, Yamada K, Noda Y, Maruyama S, Okada H, Okada N, Matsuo S, Ito Y
Organizer
XXIV International Complement Workshop
Place of Presentation
Crete, Greece, Immunobiology
Year and Date
20121010-15
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[Presentation] 急性腹膜生涯に対するアンチセンス C5a ペプチドの治療効果2012
Author(s)
水野智博, 水野正司, 櫛田真由, 野田幸裕, 山田清文, 今井優樹, 岡田秀親, 岡田則子, 丸山彰一, 松尾清一, 伊藤恭彦
Organizer
第49回補体シンポジウム
Place of Presentation
大阪成人病センター(大阪)
Year and Date
20120824-25
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[Presentation] 急性腹膜障害に対する C5a の関与と C5a 阻害薬の有用性2011
Author(s)
水野智博, 水野正司, 櫛田真由, 野田幸裕, 山田清文, 今井優樹, 岡田秀親, 岡田則子, 丸山彰一, 松尾清一, 伊藤恭彦
Organizer
第48回補体シンポジウム
Place of Presentation
名古屋市立大学医学部(名古屋)
Year and Date
20110902-03
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