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2011 Fiscal Year Final Research Report

Pathogenesis of cancer and diabetes caused by aberrant expression of sialidase

Research Project

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Project/Area Number 22659082
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionTohoku Pharmaceutical University

Principal Investigator

MIYAGI Taeko  東北薬科大学, 大学院・薬学研究科, 教授 (50006110)

Co-Investigator(Kenkyū-buntansha) SATO Ikurou  宮城県立がんセンター, 病理部, 部長 (50225918)
SIOZAKI Kazuhiro  鹿児島大学, 水産学部, 助教 (70390896)
Project Period (FY) 2010 – 2011
Keywords腫瘍 / シアリダーゼ / 癌 / 糖尿病
Research Abstract

Plasma membrane-associated sialidase is up-regulated in various human cancers including colon cancer. The transgenic mice develop hyperinsulinemia and subsequently insulin resistance, and also are susceptible to induction of colonic aberrant crypt foci by a carcinogen, azoxymethane. Analysis of the pathogenesis revealed that NEU3 activates Wnt signaling, which is thought to be important for cancer progression and also for beta cell growth in pancreatic islets, suggesting an influence of NEU3 on the two diseases probably via Wnt activation.

  • Research Products

    (13 results)

All 2012 2011 2010 Other

All Journal Article (7 results) Presentation (3 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Plasma membraneassociated sialidase(NEU3) regulates progression of prostate cancer to androgen-independent growth through modulation of androgen receptor signaling2012

    • Author(s)
      Kawamura, S., Sato, I., Wada, T., Yamaguchi, K., Li, Y., Li, D., Zhao, X., Ueno, S., Aoki, H., Tochigi, T., Kuwahara, M. Kitagawa, T., Takahashi, K., Moriya, S., Miyagi, T
    • Journal Title

      Cell Death Differ

      Volume: 19 Pages: 170-179

  • [Journal Article] Mammalian sialidases : physiological and pathological roles in cellular functions2012

    • Author(s)
      Miyagi, T., Yamaguchi, K
    • Journal Title

      Glycobiology

      Volume: 22 Pages: 880-896

  • [Journal Article] Membrane sialidase NEU3 is highly expressed in human melanoma cells promoting cell growth with minimal changes in the composition of gangliosides2011

    • Author(s)
      Miyata, M., Kambe, M., Tajima, O., Moriya, S., Sawaki, H., Hotta, H., Kondo, Y., Narimatsu, H., Miyagi, T., Furukawa, K., Furukawa, K
    • Journal Title

      Cancer Sci

      Volume: 102 Pages: 2139-2149

  • [Journal Article] Regulation of sialyl Lewis antigen expression in colon cancer cells by sialidase NEU42011

    • Author(s)
      Shiozaki, K., Yamaguchi, K., Takahashi, K., MoriyaS., Miyagi, T
    • Journal Title

      J. Biol Chem

      Volume: 286 Pages: 21052-21061

  • [Journal Article] Regulation of plasma membrane-associated sialidase NEU3 gene by Sp1/Sp3 transcription factors2010

    • Author(s)
      Yamaguchi, K., Koseki, K., Shiozaki, M., Shimada, Y., Wada, T., Miyagi, T
    • Journal Title

      Biochem, J

      Volume: 430 Pages: 107-117

  • [Journal Article] A crucial role of sialidase Neu1 in hyaluronan receptor function of CD44 in T helper type 2-mediated airway inflammation of murine acute asthmatic model2010

    • Author(s)
      Katoh S, Maeda S, Fukuoka H, Wada T, Moriya S, Mori A, Yamaguchi K, Senda S, Miyagi T
    • Journal Title

      Clin Exp Immunol

      Volume: 161 Pages: 233-241

  • [Journal Article] Mammalian sialidases and their functions2010

    • Author(s)
      Miyagi T
    • Journal Title

      Trends In Clycoscien and Glycotechnology

      Volume: 22 Pages: 162-172

  • [Presentation] Distinct functional roles between ganglioside sialidases Neu3 and Neu42011

    • Author(s)
      Miyagi, T., Yamaguchi, K., Shiozaki, K., Takahashi, K., Wada, T., Hata, K., Moriya, S., Yamamoto, K
    • Organizer
      The 31st Naito Conference : Glycan Expression and Regulation[II]: Metabolites, Stress Response, Microdomains, and Beyond
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2011-09-14
  • [Presentation] Aberrant expression of sialidase and cancer progression2011

    • Author(s)
      Miyagi, T
    • Organizer
      US-JAPA Conference : Inflammation, Diabetes, And Cancer
    • Place of Presentation
      City of Hope, Duarte CA, USA
    • Year and Date
      2011-08-04
  • [Presentation] Altered expression of sialidases in human cancer2011

    • Author(s)
      Miyagi, T., Takahashi, K., Moriya, S., Hata, K., Wada, T., Yamaguchi, K., Shiozaki, K
    • Organizer
      IXth International Symposium(IXth ISCSM, 2011) on "Biochemical Roles of Eukaryotic Cell Surface Macromolecules"
    • Place of Presentation
      Trivandrum, India
    • Year and Date
      2011-01-28
  • [Book] Structure and function of mammalian sialidases. in Topics in Current Chemistry : Sialoglyco-Biology and-Chemistry

    • Author(s)
      Monti, E. and Miyagi, T
    • Publisher
      Springer(in press)
  • [Book] Altered expression of sialidases in human cancer. Proceedings of the 9th ISCSM

    • Author(s)
      Miyagi T., Takahashi K., Moriya S., Hata K., Wada T. Yamaguchi K., Shiozaki K
    • Publisher
      Springer Publishers(in press)
  • [Remarks]

    • URL

      http://www.tohoku-pharm.ac.jp/laboratory/ganseigyo/index.html

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Published: 2013-07-31  

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