2011 Fiscal Year Final Research Report
A comprehensive analysis of interferon-inducible proteins by RNA interference screening
| Project/Area Number |
22659088
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
MATSUZAWA Takeshi 大阪府立大学, 大学院・生命環境科学研究科, 助教 (80370154)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 自然免疫 / インターフェロン / マクロファージ / 細胞内寄生菌 / RNAiスクリーングニ |
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| Research Abstract |
The aim of this study was to identify the interferon-inducible proteins, which is involved in the immunity to bacterial pathogens. This study reveals that autophagy is activated by interferon-gamma via p38 MAPK(Journal of Immunology, in press). Moreove, p38 MAPK-mediated autophagy contributes to macrophage bactericidal activity.
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