2012 Fiscal Year Final Research Report
Molecular mechanism of the infection of hepatitis B viruses
| Project/Area Number |
22659090
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | Kanazawa University |
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Principal Investigator |
KUROKI Kazuyuki 金沢大学, がん進展制御研究所, 准教授 (20178122)
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| Project Period (FY) |
2010 – 2012
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| Keywords | B型肝炎ウイルス / ウイルスベクター / HBV / DHBV / 感染 / 肝細胞 |
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| Research Abstract |
For the study of entry pathway of hepatitis B viruses, we have constructed novel hepatitis B virus vectors and attempted to identify the host molecules related to the entry pathway and to establish in vitro infection systems for these viruses. As the results, we could construct novel hepatitis B virus vectors containing secretion-type luciferases as reporter genes. Unfortunately, we could not identify the host molecules relate to DHBV infection, but we were able to find human hepatoma cell HuH7 as HBV susceptible cells under the culture condition containing 2% DMSO.
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