2011 Fiscal Year Final Research Report
Effect of the extracts of African plants on ATL cells
| Project/Area Number |
22659093
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | Kagoshima University |
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Principal Investigator |
EIZURU Yoshito 鹿児島大学, 医歯学総合研究科, 教授 (00041351)
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| Project Period (FY) |
2010 – 2011
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| Keywords | アフリカの伝統医薬 / 抗ATL細胞作用 / toosendanin / アポトーシス |
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| Research Abstract |
The cytotoxic substance was found in African traditional medicine. This substance is cytotoxic for HTLV-1-infected lymphocyte(ATL cells), but not for normal lymphocytes. The selective index is more than 1000-fold. This substance is toosendanin, consisted of the mixture of two isomers, 12-acetoxyamoorastatin and 29-deacetylsendanin. Finally, this substance causes apoptosis of HTLV-1-infected lymphocytes
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