2011 Fiscal Year Final Research Report
Mimetic virus-infection in thymic medullary microenvironment
| Project/Area Number |
22659094
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Research Collaborator |
SHIMO Yusuke 東京大学, 新領域創成科学科, 大学院生
OHSHIMA Daisuke 東京大学, 新領域創成科学科, 大学院生
SHINZAWA Miho 東京大学, 新領域創成科学, 大学院生
秋山 伸子 , 日本学術振興会特別研究員
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| Project Period (FY) |
2010 – 2011
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| Keywords | 免疫寛容 / 自己免疫 |
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| Research Abstract |
Thymus generates T cells essential for acquired immune responses against pathogens or other foreign antigens. In the thymus, T cells tolerant to self-antigens are selected. Medullary thymic epithelial cells(mTECs) play a critical role of this selection mechanism. Thus, mTECs ectopically express a wide variety of self-antigens that are normally expressed in tissue restricted manner. mTECs present these self-antigens to developing T cells, thereby eliminating the T cells responsive to self-tissues. In this study, we found that proteins induced by virus-infection were ectopically expressed in mTECs. This finding implies the novel link between natural inflammation and self-tolerant mechanism in the thymus.
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Research Products
(27 results)
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[Journal Article] RANK signaling induces interferon-stimulated genes in the fetal thymic stroma2011
Author(s)
Ohshima D., Qin J., Konno H., Hirosawa A., Shiraishi T., Yanai H., Shimo Y., Shinzawa M., Akiyama N., Yamashita R., Nakai K., Akiyama T, and Inoue J.
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 408
Pages: 530-536
DOI
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[Journal Article] Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation2011
Author(s)
Ohno T., Oboki K., Kajiwara N., Tanaka S., Ikeda M., Iikura M., Akiyama T., Inoue J., Matsumoto K., Sudo K., Azuma M., Okumura K., Kamradt T., Saito H., Nakae S.
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Journal Title
Plos One
Volume: 6
Pages: e18404
DOI
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[Journal Article] Lymphotoxin Signal Promotes Thymic Organogenesis by Eliciting RANK Expression in the Embryonic Thymic Stroma2011
Author(s)
Mouri Y., Yano M., Shinzawa M., Shimo Y., Hirota F., Nishikawa Y, Nii T., Kiyonari H., Abe T., Uehara H., Izumi K., Tamada K., Chen L., Penninger JM., Inoue J., Akiyama T, and Matsumoto M.
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Journal Title
J. Immunol.
Volume: 186
Pages: 5047-57
DOI
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[Journal Article] Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a non-canonical NF-・B pathway2010
Author(s)
Tando T, Ishizaka A, Watanabe H, Ito T, Iida S, Haraguchi T, Mizutani T, Izumi T, Isobe T, Akiyama T, Inoue J and Iba H.
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Journal Title
J. Biol. Chem.
Volume: 285
Pages: 21951-60
DOI
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[Journal Article] Human lactoferrin activates NF-kB through Toll-like receptor 4(TLR4) pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling2010
Author(s)
Ando K, Hasegawa K, Shindo K, Furusawa T, Fujino T, Kikugawa K, Nakano H, Takeuchi O, Akira S, Akiyama T, Gohda J, Inoue J, Hayakawa M.
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Journal Title
FEBS J.
Volume: 277
Pages: 2051-2066
DOI
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