2011 Fiscal Year Final Research Report
Study of the widespread of drug-resistant Enterobacteriaceae among healthy people in Japan
| Project/Area Number |
22659103
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical sociology
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| Research Institution | Osaka Prefectural Institute of Public Health (2011)
Osaka University (2010) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIRAI Itaru 大阪大学, 大学院・医学系研究科, 准教授 (00359994)
YAMAMOTO Mayumi 岐阜大学, 保健管理センター, 教授 (40313879)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 薬剤耐性菌 / 腸内細菌 / 健常人 / 日本 |
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| Research Abstract |
Multidrug-resistant pathogens that produce extended-spectrumβ-lactamases(ESBLs) have spread rapidly worldwide causing treatment failure and hindering infection control efforts. In the present study, we investigated the prevalence of the fecal carriage of ESBL-producing Enterobacteriaceae among healthy adults in Japan. We found the prevalence of ESBL producers to be 6.3% by phenotypic identification, and 84% of them possessed the bla_<CTX-M> gene. Among the CTX-M ESBL-producing Enterobacteriaceae, the majority of them was Escherichia coli. The findings suggest that the fecal carriage of ESBL producers by healthy people is rapidly increasing from the previous report that showed approximately 0.3% prevalence 10 years ago, in Japan.
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Research Products
(9 results)
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[Journal Article] Extended-spectrum beta-lactamase-producing Escherichia coli strains in the feces of carriers contribute substantially to urinary tract infections in these patients2011
Author(s)
Niki, M., Hirai, I., Yoshinaga, A., Ulzii-Orshikh, L., Nakata, A., Yamamoto, A., Yamamoto, M., Yamamoto, Y.
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Journal Title
Infection
Volume: 39
Pages: 467-471
Peer Reviewed
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[Journal Article] Prevalence of fecal carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae among healthy adult people in Japan2011
Author(s)
Luvsansharav, U. O., Hirai, I., Niki, M., Nakata, A., Yoshinaga, A., Moriyama, T., Yamamoto, Y.
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Journal Title
J. Infect. Chemother
Volume: 60
Pages: 619-624
Peer Reviewed
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