2011 Fiscal Year Final Research Report
Establishment of novel forensic diagnostic methods based on biological clock
| Project/Area Number |
22659137
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Legal medicine
|
|---|
| Research Institution | Wakayama Medical University |
|---|
Principal Investigator |
KIMURA Akihiko 和歌山県立医科大学, 医学部, 准教授 (60136611)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KONDO Toshikazu 和歌山県立医科大学, 医学部, 教授 (70251923)
ISHIDA Yuko 和歌山県立医科大学, 医学部, 講師 (10364077)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NOSAKA Mizuho 和歌山県立医科大学, 医学部, 助教 (00244731)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 体内時計 / 法医診断 / 時計遺伝子 / Real-time PCR |
|---|
| Research Abstract |
Biological clock exists in most tissues and is involved in their homeostasis. Malfunction of biological clock can cause various diseases. In this study, we examined the possibility that forensic diagnosis can be performed by analysis of biological clock in the tissues. We found that significant reduction of clock gene expression in the hypertrophic heart, kidney damaged with a toxic compound and injured skin tissue, suggesting that biological clock in the damaged tissues might be a novel diagnostic marker in forensic medicine.
|
