Periodontal bacteria as one of the risk factors for developing of Non-alcoholic steato-hepatitis(NASH)

2011 Fiscal Year Final Research Report

• Project/Area Number: 22659150
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Yokohama City University
• Principal Investigator: ABE Yasunobu 横浜市立大学, 医学部, 助教 (10347312)
• Co-Investigator(Kenkyū-buntansha): NAKAJIMA Atsushi 横浜市立大学, 附属病院, 教授 (30326037) ; WADA Koichiro 大阪大学, 歯学研究科, 准教授 (90263467)
• Project Period (FY): 2010 – 2011
• Keywords: 歯周病 / 非アルコール性脂肪肝炎

Research Abstract

The detection frequency of P. gingivalis in NAFLD patients was significantly higher than that in the non-NAFLD control subjects(46.7% vs. 21.7%, odds ratio : 3.16). In addition, the detection frequency of P. gingivalis in NASH patients was markedly higher than that in the non-NAFLD subjects(52.0%, odds ratio : 3.91). Most of the P. gingivalis fimbria detected in the NAFLD patients was of invasive genotypes, especially type II(50.0%). Infection of type II P. gingivalis on NAFLD model of mice accelerated the NAFLD progression. The non-surgical periodontal treatments on NAFLD patients carried out for 3 months ameliorated the liver function parameters, such as the serum levels of AST and ALT.

Research Products

• [Journal Article] Imaging findings of pancreatic cystic lesions in von hippel-lindau disease (2012)
  • Author(s): Kobayashi N, Sato T, Kato S, Watanabe S, Hosono K, Shimamura T, Iida H, Endo H, Koide T, Takahashi H, Yoneda M, Shibata W, Abe Y, Inamori M, Kirikoshi H, Saito S, Maeda S, Nakajima A, Kubota K.
  • Journal Title: Intern Med Volume: 51(11) Pages: 1301-7
• [Journal Article] Risk Factors for Colonic Diverticular Hemorrhage : Japanese Multicenter Study (2012)
  • Author(s): Suzuki K, Uchiyama S, Imajyo K, Tomeno W, Sakai E, Yamada E, Tanida E, Akiyama T, Watanabe S, Endo H, Fujita K, Yoneda M, Takahashi H, Koide T, Tokoro C, Abe Y, Kawaguchi M, Gotoh E, Maeda S, Nakajima A, Inamori M.
  • Journal Title: Digestion Volume: 85(4) Pages: 261-265
• [Journal Article] Early effect of oral administration ofomeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH (2012)
  • Author(s): Iida H, Inamori M, Fujii T, Sekino Y, Endo H, Hosono K, Nonaka T, Koide T, Takahashi H, Yoneda M, Goto A, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Gotoh E, Maeda S, Nakajima A.
  • Journal Title: BMC Gastroenterol Volume: 26 Pages: 12-25
• [Journal Article] Early effects of oral administration of omeprazole and roxatidine on intragastric pH (2012)
  • Author(s): Iida H, Kato S, Sekino Y, Sakai E, Uchiyama T, Endo H, Hosono K, Sakamoto Y, Fujita K, Yoneda M, Koide T, Takahashi H, Tokoro C, Goto A, Abe Y, Kobayashi N, Kubota K, Gotoh E, Maeda S, Nakajima A, Inamori M.
  • Journal Title: J Zhejiang Univ Sci B Volume: 13(1) Pages: 29-34
• [Journal Article] A New Non-Invasive Modality for Recording SequentialImages and the pH of the Small Bowel (2012)
  • Author(s): Iida H, Endo H, Sekino Y, Sakai E, Uchiyama T, Hosono K, Nonaka T, Sakamoto Y, Fujita K, Yoneda M, Koide T, Takahashi H, Tokoro C, Goto A, Abe Y, Gotoh E, MaedaS, Nakajima A, Inamori M.
  • Journal Title: Hepatogastroenterology Volume: 59(114) Pages: 413-4
• [Journal Article] Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease (2012)
  • Author(s): Yoneda M, Naka S, Nakano K, Wada K, Endo H, Mawatari H, Imajo K, Nomura R, Hokamura K, Ono M, Murata S, Tohnai I, Sumida Y, Shima T, Kuboniwa M, Umemura K, Kamisaki Y, Amano A, Okanoue T, Ooshima T, Nakajima A.
  • Journal Title: BMC Gastroenterol Volume: 16 Pages: 12-16
• [Journal Article] Effective treatment for duodenal variceal bleeding using endoscopic ligation. Hepatogastroenterology (2011)
  • Author(s): Kawakami Y, Takahashi H, Kato S, Uchiyama T, Mawatari H, Iida H, Inamori M, Abe Y, Nakajima A.
  • Journal Title: Hepatogastroenterology Volume: 58(112) Pages: 2024-5
• [Journal Article] Mosapride accelerates the delayed gastric emptying of high-viscosity liquids : a crossover study using continuous real-time C breath test(BreathID System) (2011)
  • Author(s): Sakamoto Y, Sekino Y, Yamada E, Ohkubo H, Higurashi T, Sakai E, Iida H, Hosono K, Endo H, Nonaka T, Ikeda T, Fujita K, Yoneda M, Koide T, Takahashi H, Goto A, Abe Y, Gotoh E, Maeda S, Nakajima A, Inamori M.
  • Journal Title: J Neurogastroenterol Motil Volume: 17(4) Pages: 395-401
• [Journal Article] Time-course of changes of visceral fat area, liver volume and liver fat area during intragastric balloon therapy in Japanese super-obese patients (2011)
  • Author(s): Sekino Y, Imajo K, Sakai E, Uchiyama T, Iida H, Endo H, Hosono K, Sakamoto Y, Fujita K, Yoneda M, Takahashi H, Koide T, Tokoro C, Abe Y, Saito S, Maeda S, Gotoh E, Takihata M, Terauchi Y, Nakajima A, Inamori M.
  • Journal Title: Intern Med Volume: 50(21) Pages: 2449-55
• [Journal Article] Effects of Histamine-2 Receptor Antagonists and Proton Pump Inhibitors on the Rate of Gastric Emptying : A Crossover Study Using a Continuous Real-Time C Breath Test(BreathID System) (2011)
  • Author(s): Nonaka T, Kessoku T, Ogawa Y, Imajyo K, Yanagisawa S, Shiba T, Sakaguchi T, Atsukawa K, Takahashi H, Sekino Y, Sakai E, Uchiyama T, Iida H, Hosono K, Endo H, Sakamoto Y, Fujita K, Yoneda M, Koide T, Takahashi H, Tokoro C, Abe Y, Gotoh E, Maeda S, Nakajima A, Inamori M.
  • Journal Title: J Neurogastroenterol Motil Volume: 17(3) Pages: 287-93
• [Journal Article] Localized primary AL amyloidosis of the colon without other GI involvement (2011)
  • Author(s): Tokoro C, Inamori M, Sekino Y, Sakai E, Uchiyama T, Iida H, Hosono K, Endo H, Sakamoto Y, Takahashi H, Koide T, Yasuzaki H, Goto A, Abe Y, Kawana I, Nakajima A, Maeda S, Oshiro H, Inayama Y.
  • Journal Title: Gastrointest Endosc Volume: 74(4) Pages: 925-6
• [Journal Article] Solitary Peutz-Jeghers type hamartomatous polyps in the duodenum are not always associated with a low risk of cancer : two case reports (2011)
  • Author(s): Sekino Y, Inamori M, Hirai M, Suzuki K, Tsuzawa K, Akimoto K, Takahata A, Fujisawa N, Saito K, Tsunemi A, Tanaka M, Iida H, Sakamoto Y, Takahashi H, Koide T, Tokoro C, Abe Y, Nakajima A, Maeda S, Koyama S.
  • Journal Title: J Med Case Rep Volume: 27 Pages: 5-240
• [Journal Article] Effects of domperidone on gastric emptying : a crossover study using a continuous real-time 13C breath test(BreathID system) (2011)
  • Author(s): Sakamoto Y, Kato S, Sekino Y, Sakai E, Uchiyama T, Iida H, Hosono K, Endo H, Fujita K, Koide T, Takahashi H, Yoneda M, Tokoro C, Goto A, Abe Y, Kobayashi N, Kubota K, Maeda S, Nakajima A, Inamori M.
  • Journal Title: Hepatogastroenterology Volume: 58(106) Pages: 637-41
• [Journal Article] Risk factors for mortality in patients with Mallory-Weiss syndrome (2011)
  • Author(s): Fujisawa N, Inamori M, Sekino Y, Akimoto K, Iida H, Takahata A, Endo H, Hosono K, Sakamoto Y, Akiyama T, Koide T, Tokoro C, Takahashi H, Saito K, Abe Y, Nakamura A, Kubota K, Saito S, Koyama S, Nakajima A.
  • Journal Title: Hepatogastroenterology Volume: 58 Pages: 417-20
• [Journal Article] Change of gastric emptying with chewing gum : evaluation using a continuous real-time C breath test(BreathID system) (2011)
  • Author(s): Sakamoto Y, Kato S, Sekino Y, Sakai E, Uchiyama T, Iida H, Hosono K, Endo H, Fujita K, Koide T, Takahashi H, Yoneda M, Tokoro C, Goto A, Abe Y, Kobayashi N, Kubota K, Maeda S, Nakajima A, Inamori M.
  • Journal Title: J Neurogastroenterol Motil Volume: 17(2) Pages: 174-9
• [Journal Article] Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users : a pilot randomized controlled study (2011)
  • Author(s): Endo H, Higurashi T, Hosono K, Sakai E, Sekino Y, Iida H, Sakamoto Y, Koide T, Takahashi H, Yoneda M, Tokoro C, Inamori M, Abe Y, Nakajima A.
  • Journal Title: J Gastroenterol Volume: 46(7) Pages: 894-905
• [Journal Article] Influence of pretreatment with H2 receptor antagonists on the cure rates of Helicobacter pylori eradication (2011)
  • Author(s): Tokoro C, Inamori M, Koide T, Sekino Y, Iida H, Sakamoto Y, Endo H, Hosono K, Takahashi H, Yoneda M, Yasuzaki H, Ogawa M, Abe Y, Kubota K, Saito S, Kawana I, Nakajima A, Maeda S, Matsuda R, Takahashi D.
  • Journal Title: Med Sci Monit Volume: 17(5) Pages: CR235-40
• [Journal Article] Early effects of oral administration of lafutidine with peppermint oil, compared with lafutidine alone, on intragastric pH values (2011)
  • Author(s): Iida H, Inamori M, Uchiyama T, Endo H, Hosono K, Akiyama T, Sakamoto Y, Fujita K, Takahashi H, Yoneda M, Koide T, Tokoro C, Goto A, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A.
  • Journal Title: Hepatogastroenterology Volume: 58(105) Pages: 235-8
• [Journal Article] Does postprandial itopride intake affect the rate of gastric emptying? A crossover study using the continuous real time 13C breath test(BreathID system) (2011)
  • Author(s): Nonaka T, Kessoku T, Ogawa Y, Yanagisawa S, Shiba T, Sahaguchi T, Atsukawa K, Takahashi H, Sekino Y, Iida H, Hosono K, Endo H, Sakamoto Y, Koide T, Takahashi H, Tokoro C, Abe Y, Maeda S, Nakajima A, Inamori M.
  • Journal Title: Hepatogastroenterology Volume: 58(105) Pages: 224-8
• [Journal Article] Optimal approach for small bowel capsule endoscopy using polyethylene glycol and metoclopramide with the assistance of a real-time viewer (2011)
  • Author(s): Hosono K, Endo H, Sakai E, Sekino Y, Uchiyama T, Watanabe S, Iida H, Sakamoto Y, Koide T, Takahashi H, Yoneda M, Tokoro C, Abe Y, Inamori M, Kobayashi N, Kubota K, Nakajima A.
  • Journal Title: Digestion Volume: 84 Pages: 119-25
• [Journal Article] The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke (2011)
  • Author(s): Nakano K, Hokamura K, Taniguchi N, Wada K, Kudo C, Nomura R, Kojima A, Naka S, Muranaka Y, Thura M, Nakajima A, Masuda K, Nakagawa I, Speziale P, Shimada N, Amano A, Kamisaki Y, Tanaka T, Umemura K, Ooshima T.
  • Journal Title: Nat Commun Volume: 2 Pages: 485
• [Journal Article] Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis (2011)
  • Author(s): Endo H, Hosono K, Uchiyama T, Sakai E, Sugiyama M, Takahashi H, Nakajima N, Wada K, Takeda K, Nakagama H, Nakajima A.
  • Journal Title: Gut Volume: 60(10) Pages: 1363-71
• [Journal Article] Characterization of aortic aneurysms in cardiovascular disease patients harboring Porphyromonas gingivalis (2011)
  • Author(s): Nakano K, Wada K, Nomura R, Nemoto H, Inaba H, Kojima A, Naka S, Hokamura K, Mukai T, Nakajima A, Umemura K, Kamisaki Y, Yoshioka H, Taniguchi K, Amano A, Ooshima T.
  • Journal Title: Oral Dis Volume: 17(4) Pages: 370-8
• [Journal Article] Does pretreatment with proton pump inhibitors influence the eradication rate of Helicobacter pylori? (2010)
  • Author(s): Tokoro C, Inamori M, Koide T, Iida H, Sakamoto Y, Endo H, Hosono K, Takahashi H, Yoneda M, Yasuzaki H, Ogawa M, Abe Y, Kubota K, Saitou S, Kawana I, Matsuda R, Takahashi D, Nakajima A.
  • Journal Title: Hepatogastroenterology Volume: 57 Pages: 1645-9
  • DOI: DOI:10.1016/j.bmcl.2011.11.045.