2011 Fiscal Year Final Research Report
Pathophysiological Roles of Mesenchymal Stem Cells and Hematopoietic Stem Cells in Hepatic Fibrosis
| Project/Area Number |
22659152
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Tokai University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
MATSUZAKI Yumi 慶応義塾大学, 医学部, 准教授 (50338183)
HIGASHIYAMA Reiichi 東海大学, 医学部, 奨励研究員 (80459495)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 肝線維化 / 骨髄幹細胞 |
|---|
| Research Abstract |
There are two types of stem cells, hematopoietic stem cells(HSC) and mesenchymal stem cells(MSC), present in bone marrow(BM). While HSC have been well characterized and applied for BM transplantation, little is known about the physiological roles of MSC. In this study, we have revealed that hematopoietic cells derived from HSC migrate into fibrotic liver and contribute the regression of fibrosis by expressing collagenases. In contrast, MSC or its derivatives are not mobilized from BM into fibrotic liver tissue during hepatic fibrogenesis.
|
