2011 Fiscal Year Final Research Report
A significance of integrated stress response in the heart
| Project/Area Number |
22659158
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
SANO Motoaki 慶應義塾大学, 医学部, 講師 (30265798)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ストレス応答 |
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| Research Abstract |
We created and analyzed αMHC-Fv2E-PERK mice(an inducible eIF2α activator mice) and α MHC-Gadd34C mice(a loss of function model of eIF2α). Notably, the strong activation of eIF2αtriggered by dimerization of PERK transiently suppressed left ventricular systolic function. Left ventricular systolic function was gradually recovered in survivor mice. The strong activation of eIF2α was observed in the severe ischemia. Therefore, we hypothesized that the transient impairment of left ventricular systolic function is resemble to stunned myocardium. We are currently investigating the underlying mechanism of the transient impairment of left ventricular systolic function.
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