2011 Fiscal Year Final Research Report
Development research of ghrelin treatment against intractable respiratory diseases
| Project/Area Number |
22659161
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Nobuhiro 宮崎大学, 医学部, 助教 (70418838)
YANAGI Shigehisa 宮崎大学, 医学部, 助教 (60404422)
MIYOSHI Kahori 宮崎大学, 医学部, 医員 (50573375)
TSUBOUCHI Hironobu 宮崎大学, 医学部, 医員 (60573988)
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| Project Period (FY) |
2010 – 2011
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| Keywords | グレリン / 肺癌 / 漢方薬 / 慢性呼吸不全 / 肺傷害 / Pten / QOL / カヘキシア |
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| Research Abstract |
In this study, we explored the pathophysiological significance of ghrelin in intractable respiratory diseases. From clinical view, we found an inverse correlation between plasma ghrelin levels at pre-chemotherapy point and degree of chemotherapy-related decline of QOL score in patients with advanced lung cancer. We also found beneficial effects of ghrelin treatment on nutritional status and exercise tolerance in patients with chronic respiratory failure. In animal models, ghrelin administration definitively rescued bleomycin-treated mice in a dose-dependent manner. Ghrelin treatment ameliorated lung inflammation, lung fibrosis and apoptosis of alveolar epithelial cells after lung injury. These results indicate that ghrerin might be an attractive therapeutic strategy against these refractory lung diseases.
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[Journal Article] Significant lowering of plasma ghrelin but not des-acyl ghrelin in response to acute exercise in men2011
Author(s)
Shiiya T, Ueno H, Toshinai K, Kawagoe T, Naito S, Tobina T, Nishida Y, Shindo M, Kangawa K, Tanaka H, Nakazato M
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Journal Title
Endocr J
Volume: 58
Pages: 335-342
Peer Reviewed
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[Journal Article] Regulation of ghrelin signaling by a leptin-induced gene, negative regulatory element-binding protein, in the hypothalamic neurons2010
Author(s)
Komori T, Doi A, Furuta H, Wakao H, Nakao N, Nakazato M, Nanjo K, Senba E, Morikawa Y
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Journal Title
J Biol Chem
Volume: 285
Pages: 37884-37894
Peer Reviewed
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[Journal Article] Ghrelin Treatment of Cachectic Patients with Chronic Obstructive Pulmonary Disease : a multicenter, randomized, double-blind, placebo-controlled trial
Author(s)
Miki K, Maekura R, Nagaya N, Nakazato M, Kimura H, Murakami S, Ohnishi S, Hiraga T, Miki M, Kitada S, Yoshimura K, Arimura Y, Matsumoto N, Yoshikawa M, Yamahara K, Kangawa K
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Journal Title
PLoS ONE
Volume: (in press)
Peer Reviewed
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