2011 Fiscal Year Final Research Report
Role of amine-carbonyl reaction as a novel mechanism for renal disease
| Project/Area Number |
22659164
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
ITO Sadayoshi 東北大学, 大学院・医学系研究科, 教授 (40271613)
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| Project Period (FY) |
2010 – 2011
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| Keywords | アミン / カルボニル / 慢性腎臓病 / 急性腎障害 |
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| Research Abstract |
The study was designed to evaluate whether reaction between amine and carbonyl compound is a novel mechanism for renal injury. Renal injury was observed by co-administration of MGO and melamine or oxonic acid. This reaction was also inhibited by pyridoxamine treatment. These results indicate that amine-carbonyl reaction could be a novel therapeutic mechanism which could be targeted for renal injuries.
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