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2011 Fiscal Year Final Research Report

Regulatory roles of 25(OH) vitamin D on lipid raft

Research Project

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Project/Area Number 22659166
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Kidney internal medicine
Research InstitutionOsaka University

Principal Investigator

MATSUI Isao  大阪大学, 大学院・医学系研究科, 助教 (60456986)

Project Period (FY) 2010 – 2011
Keywordsvitamin D / 25(OH) vitamin D / lipid raft / 腎保護 / 血管保護 / レニン
Research Abstract

In this research, we showed that 25-hydroxyvitamin D[ 25(OH) D] itself has biological effects. The effects of 25(OH) D did not require its activation to 1, 25-dihydroxyvitamin D[ 1, 25(OH)_2D]. Our results suggested that 25(OH) D directly activates vitamin D receptor(VDR). Moreover, 25(OH) D modulated the functions of lipid raft.

  • Research Products

    (7 results)

All 2012 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results) Book (1 results)

  • [Journal Article] Combined Use of Vitamin D Status and FGF23 for Risk Stratification of Renal Outcome2012

    • Author(s)
      Nakano C, Hamano, T, Fujii N, Matsui I, Tomida K, Mikami S, Inoue K, Obi Y, Okada N, Tsubakihara Y, Isaka Y, Rakugi H
    • Journal Title

      Clin J Am Soc Nephrol

      Volume: Vol.7 Pages: 810-819

    • Peer Reviewed
  • [Presentation] Maxacalcitolはレニン抑制非依存的にUUOモデルラットの腎尿細管間質病変を改善する2011

    • Author(s)
      井上和則、松井功
    • Organizer
      The 5th Kidney Frontier
    • Place of Presentation
      東京
    • Year and Date
      2011-12-17
  • [Presentation] Maxacalcitol ameliorates tubulointer stitial fibrosis in the obstructed kidney2011

    • Author(s)
      Kazunori Inoue, Isao Matsui
    • Organizer
      The 44th Meeting of the American society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2011-11-11
  • [Presentation] Combinational Usage of Vitamin D Status and the Earliest Marker Fibroblast Growth Factor 23 Improves Risk Stratification for Renal Outcome2011

    • Author(s)
      hikako Nakano, Takayuki Hamano, Naohiko Fujii, Isao Matsui, Kodo Tomida, Kazunori Inoue, Akihiro Shimomura, Yoshitsugu Obi, Hiromi Rakugi, Yoshitaka Isaka
    • Organizer
      The 44th Meeting of the American society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2011-11-11
  • [Presentation] Maxacalcitolはレニン抑制非依存的にUUOモデルラットの腎尿細管間質病変を改善する2011

    • Author(s)
      井上和則、松井功
    • Organizer
      Bone Research Joint Meeting
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-08
  • [Presentation] A Comprehensive Approach for Predicting Renal Outcome by Laboratory Factors in CKD-MBD2011

    • Author(s)
      Chikako Nakano, Takayuki Hamano, Naohiko Fujii, Isao Matsui, Kodo Tomida, Yoshitsugu Obi, Hiromi Rakugi, Yoshitaka Isaka
    • Organizer
      XLVIII European Reanl Association. European Dialysis and Transplant Association Congress
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2011-06-26
  • [Book] ビタミンDの腎保護作用2010

    • Author(s)
      松井功
    • Total Pages
      256-256
    • Publisher
      医学のあゆみ

URL: 

Published: 2013-07-31  

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