2011 Fiscal Year Final Research Report
Elucidate the pathomechanism of inclusion body myositis(IBM)
| Project/Area Number |
22659167
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
ITOYAMA Yasuto 独立行政法人国立精神・神経医療研究センター, 病院, 院長 (30136428)
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| Co-Investigator(Kenkyū-buntansha) |
AOKI Masashi 東北大学, 医学系・研究科, 教授 (70302148)
SUZUKI Naoki 東北大学, 病院, 助教 (70451599)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 神経分子病態学 / 筋萎縮 / 封入体筋炎 / 自己抗体 / プロテアソーム |
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| Research Abstract |
Sporadic inclusion body myositis(sIBM) is an intractable and progressive skeletal muscle disease of unknown cause and without effective treatment. Our purpose is to elucidate the pathomechanism of sIBM exploring the autoantibody in the serum of sIBM patients using protein array. We also produced muscle specific proteasome deficient mice as the disease model of sIBM.
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