2012 Fiscal Year Final Research Report
Study on possible transmission of Alzheimer's disease with medical procedures and food
| Project/Area Number |
22659170
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ONO Kenjiro 金沢大学, 附属病院, 講師 (70377381)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | アルツハイマー病 / 医療行為 / 食品 / アミロイド / アミロイドβ蛋白 / 伝播 |
|---|
| Research Abstract |
Alzheimer’s disease (AD) may be transmissible by seeding or cross-seeding effects of exogenous protein aggregates through medical procedures, food, and so on. The purpose of this study is to determine whether Aβ or non-Aβ aggregates promote Aβ aggregation in in vitro and in vivo AD models. We found that fibrillar fragments of α-synuclein, fibroin, sericin, actin, casein, as well as Aβ40 and Aβ42 promoted aggregation of Aβ40 and Aβ42 in vitro. An in vivo study with AD model mice to which the aggregates of these proteins were administered is ongoing to reveal possible induction of AD by these protein aggregates.
|
