2011 Fiscal Year Final Research Report
Development of a drug for the polyglutamine diseases by molecular design of chemical analogues of the aggregation inhibitor peptide QBP1
| Project/Area Number |
22659172
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
NAGAI Yoshitaka 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 室長 (60335354)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Mari (独)国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 外来研究員 (20455405)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 神経変性疾患 / ポリグルタミン病 / 蛋白質 / 凝集 / アミロイド / 治療薬 / ペプチド / 分子デザイン |
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| Research Abstract |
Toward developing a drug for the polyglutamine(polyQ) neurodegenerative diseases by molecular design of chemical analogues of the aggregation inhibitor peptide QBP1, 1) we identified the minimal sequence of QBP1(WKWWPGIF) and five essential residues within QBP1 for its activity. We also found a tight correlation between their aggregation inhibitory activity and polyQ binding affinity. 2) We further showed by NMR analyses that the polyQ stretch does not adopt an ordered structure in the QBP1-polyQ complex.
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[Journal Article] Genetic and clinical analysis in a Chinese parkinsonism-predominant spinocerebellar ataxia type 2 family2011
Author(s)
Sun H, Satake W, Zhang C, Nagai Y, Tian Y, Fu S, Yu J, Qian Y, Qian Y, Chu J, Toda T
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Journal Title
J Hum Genet
Volume: 56(4)
Pages: 330-334
DOI
Peer Reviewed
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[Journal Article] Genetic Testing for Huntington's Disease in Parkinsonism2010
Author(s)
Rahman MS, Nagai Y, Popiel HA, Fujikake N, Okamoto Y, Ahmed MU, Islam MA, Islam MT, Ahmed S, Rahman KM, Uddin MJ, Dey SK, Ahmed Q, Hossain MA, Jahan N, Toda T
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Journal Title
Mymensingh Med J
Volume: 19(4)
Pages: 510-514
URL
Peer Reviewed
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