2011 Fiscal Year Final Research Report
CD1/lipid immunity-based vaccines against AIDS
| Project/Area Number |
22659188
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Infectious disease medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IGARASHI Tatsuhiko 京都大学, ウイルス研究所, 教授 (90467431)
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| Project Period (FY) |
2010 – 2011
|
| Keywords | 感染症防御学 / リポペプチド / エイズ / ワクチン / CD1 |
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| Research Abstract |
Effective protein vaccines against infection with human immunodeficiency virus remain to be established. The difficulties arise from the frequent escape mutations, and thus, identification of T cell epitopes that admit of no arbitrary mutations is crucial. We have identified cytotoxic T cell responses to myristoylated Nef peptides(lipopeptides) both in cell culture and in the monkey model of human AIDS. Because the protein myristoylation occurs in highly conserved amino acid sequences and is critical for virulence, the present study underscored the possibility that lipopeptides could be an ideal target for anti-AIDS vaccines.
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