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2012 Fiscal Year Final Research Report

Genome wide analysis of imprinting gene in pediatric solid tumor

Research Project

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Project/Area Number 22659196
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionGunma Institute of Public Health and Environmental Sciences

Principal Investigator

HAYASHI Yasuhide  群馬県衛生環境研究所, 研究企画係, 研究員 (30238133)

Co-Investigator(Kenkyū-buntansha) PARK Myoung-ja  群馬県衛生環境研究所, 研究企画係, 研究員 (50450375)
SANO Hirozumi  群馬県衛生環境研究所, 研究企画係, 研究員 (20469878)
OHKI Kentaro  群馬県衛生環境研究所, 研究企画係, 研究員 (50400966)
Co-Investigator(Renkei-kenkyūsha) SHIBA Norio  群馬大学, 医学部附属病院小児科 (50600615)
Project Period (FY) 2010 – 2012
Keywords小児腫瘍学
Research Abstract

Analysis of ALK mutation in 99 cases with Ewing sarcoma revealed 4 novel missense mutations. Functional analysis of ALK showed autophosphorylation and tumor formation in nude mouse. Another mechanism of aberrant ALK activation was observed in a neuroblastoma cell line, in which a short-form ALK protein having a truncated extracellular domain is overexpressed. ALK-transduced NIH3T3 cells exhibited increased colony-forming capacity in soft agar and tumorigenicity in nude mice. SNP array analyses of 55 rhabdomyosarcoma(RMS) samples showed that the embrynal RMS was characterized by hyperploidy, significantly associated with gains of chromosomes 2, 8 and 12, whereas the majority of alveolar RMS cases exhibited near-diploid copy number profiles. Loss of heterozygosity of 15q was highly detected in alveolar RMS. Gain of 13q was significantly associated with good patient outcome in embryonal RMS.

  • Research Products

    (57 results)

All 2013 2012 2011 2010

All Journal Article (29 results) (of which Peer Reviewed: 29 results) Presentation (28 results)

  • [Journal Article] Cytomegalovirus Retinitis During Maintenance Therapy for T-Cell Acute Lymphoblastic Leukemia.2013

    • Author(s)
      Wakai K, Sano H, Shimada A, Shiozawa Y, Park MJ, Sotomatsu M, Yanagisawa R, Koike K, Kozawa K, Ryo A, Tsukagoshi H, Kimura H, Hayashi Y
    • Journal Title

      J Pediatr Hematol Oncol

      Volume: 35 Pages: 162-163

    • DOI

      doi: 10.1097/MPH.0b013e318279e920

    • Peer Reviewed
  • [Journal Article] Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome2012

    • Author(s)
      Toki T, Kanezaki R, Kobayashi E, Kaneko H, Suzuki M, Wang R, Terui K, Kanegane H, Maeda M, Endo M, Mizuochi T, Adachi S, Hayashi Y, Yamamoto M, Shimizu R, Ito E
    • Journal Title

      Blood

      Volume: 12 Pages: 3181-3184

    • DOI

      doi: 10.1182/ blood-2012-01-405746

    • Peer Reviewed
  • [Journal Article] An Inv(16)(p13.3q24.3)-Encoded CBFA2T3- GLIS2 Fusion Protein Defines an Aggressive Subtype of Pediatric Acute Megakaryoblastic Leukemia2012

    • Author(s)
      Gruber TA, Larson Gedman A, Zhang J, Koss CS, Marada S, Ta HQ, Chen SC, Su X, Ogden SK, Dang J, Wu G, Gupta V, Andersson AK, Pounds S, Shi L, Easton J, Barbato MI, Mulder HL, Manne J, Wang J, Rusch M, Ranade S, Ganti R, Parker M, Ma J, Radtke I, Ding L, Cazzaniga G, Biondi A, Kornblau SM, Ravandi F, Kantarjian H, Nimer SD, Dohner K, Dohner H, Ley TJ, Ballerini P, Shurtleff S, Tomizawa D, Adachi S, Hayashi Y, Tawa A, Shih LY, Liang DC, Rubnitz JE, Pui CH, Mardis ER, Wilson RK, Downing JR.
    • Journal Title

      Cancer Cell

      Volume: 22 Pages: 683-697

    • DOI

      doi: 10.1016/j.ccr.2012.10.007

    • Peer Reviewed
  • [Journal Article] High WT1 mRNA expression after induction chemotherapy and FLT3-ITD have prognostic impact in pediatric acute myeloid leukemia: a study of the Japanese Childhood AML Cooperative Study Group2012

    • Author(s)
      Shimada A, Taki T, Koga D, Tabuchi K, Tawa A, Hanada R, Tsuchida M, Horibe K, Tsukimoto I, Adachi S, Kojima S, Hayashi Y
    • Journal Title

      Int J Hematol

      Volume: 96 Pages: 469-476

    • DOI

      doi: 10.1007/s12185-012-1163-1

    • Peer Reviewed
  • [Journal Article] Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia2012

    • Author(s)
      Doisaki S, Muramatsu H, Shimada A, Takahashi Y, Mori-Ezaki M, Sato M, Kawaguchi H, Kinoshita A, Sotomatsu M, Hayashi Y, Furukawa-Hibi Y, Yamada K, Hoshino H, Kiyoi H, Yoshida N, Sakaguchi H, Narita A, Wang X, Ismael O, Xu Y, Nishio N, Tanaka M, Hama A, Koike K, Kojima S
    • Journal Title

      Blood

      Volume: 120 Pages: 1485-1488

    • DOI

      doi: 10.1182/blood- 2012-02-406090

    • Peer Reviewed
  • [Journal Article] Childhood acute myeloid leukemia with bone marrow eosinophilia caused by t(16;21)(q24;q22)2012

    • Author(s)
      Kawashima N, Shimada A, Taketani T, Hayashi Y, Yoshida N, Matsumoto K, Takahashi Y, Kojima S, Kato K
    • Journal Title

      Int J Hematol

      Volume: 95 Pages: 577-580

    • DOI

      doi: 10.1007/s12185-012-1044-7

    • Peer Reviewed
  • [Journal Article] RAS mutations are frequent in FAB type M4 and M5 of acute myeloid leukemia, and related to late relapse: a study of the Japanese Childhood AML Cooperative Study Group2012

    • Author(s)
      Sano H, Shimada A, Taki T, Murata C, Park MJ, Sotomatsu M, Tabuchi K, Tawa A, Kobayashi R, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Hayashi Y
    • Journal Title

      Int J Hematol

      Volume: 95 Pages: 509-515

    • DOI

      doi: 10.1038/leu.2012.45

    • Peer Reviewed
  • [Journal Article] Novel splicing factor mutations in juvenile myelomonocytic leukemia2012

    • Author(s)
      Takita J, Yoshida K, Sanada M, Nishimura R, Okubo J, Motomura A, Hiwatari M, Oki K, Igarashi T, Hayashi Y, Ogawa S
    • Journal Title

      Leukemia

      Volume: 26 Pages: 1879-1898

    • DOI

      doi: 10.1038/leu.2012.45

    • Peer Reviewed
  • [Journal Article] Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia2012

    • Author(s)
      Yokoyama T, Toki T, Aoki Y, Kanezaki R, Park MJ, Kanno Y, Takahara T, Yamazaki Y, Ito E, Hayashi Y, Nakamura T
    • Journal Title

      Blood

      Volume: 119 Pages: 2608-2611

    • DOI

      doi: 10.1182/blood -2010-12-324806

    • Peer Reviewed
  • [Journal Article] Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma2012

    • Author(s)
      Okubo J, Takita J, Chen Y, Oki K, Nishimura R, Kato M, Sanada M, Hiwatari M, Hayashi Y, Igarashi T, Ogawa S
    • Journal Title

      Oncogene

      Volume: 31 Pages: 4667-4676

    • DOI

      doi: 10.1038/onc.2011.616

    • Peer Reviewed
  • [Journal Article] CBL mutation in chronic myelomonocytic leukemia secondary to familial platelet disorder with propensity to develop acute myeloid leukemia2012

    • Author(s)
      Shiba N, Hasegawa D, Park MJ, Murata C, Matsubara A, Ogawa C, Manabe A, Arakawa H, Ogawa S, Hayashi Y
    • Journal Title

      Blood

      Volume: 119 Pages: 2612-2614

    • DOI

      doi: 10.1182/blood-2011-02-333435

    • Peer Reviewed
  • [Journal Article] Clinical significance of early T-cell precursor acute lymphoblastic leukaemia: Results of the Tokyo Children's Cancer Study Group Study L99-152012

    • Author(s)
      Inukai T, Kiyokawa N, Campana D, Coustan-Smith E, Kikuchi A, Kobayashi M, Takahashi H, Koh K, Manabe A, Kumagai M, Ikuta K, Hayashi Y, Tsuchida M, Sugita K, Ohara A
    • Journal Title

      Brit J Haematol

      Volume: 156 Pages: 358-365

    • DOI

      doi: 10. 1111/j.1365-2141.2011.08955.x

    • Peer Reviewed
  • [Journal Article] DNMT3A mutations are rare in childhood acute myeloid leukaemia, myelodysplastic syndromes and juvenile myelomonocytic leukaemia2012

    • Author(s)
      Shiba N, Taki T, Park MJ, Shimada A, Sotomatsu M, Adachi S, Tawa A, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Arakawa H, Hayashi Y
    • Journal Title

      Br J Haematol

      Volume: 156 Pages: 413-414

    • DOI

      doi: 10. 1111/j.1365-2141.2011.08879.x

    • Peer Reviewed
  • [Journal Article] CBL mutations in infant acute lymphoblastic leukaemia2012

    • Author(s)
      Shiba N, Park MJ, Taki T, Takita J, Hiwatari M, Kanazawa T, Sotomatsu M, Ishii E, Arakawa H, Ogawa S, Hayashi Y
    • Journal Title

      Br J Haematol

      Volume: 156 Pages: 672-674

    • DOI

      doi: 10.1111/ j.1365-2141.2011.08900.x

    • Peer Reviewed
  • [Journal Article] Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma2011

    • Author(s)
      Takita J, Chen Y, Okubo J, Sanada M, Adachi M, Ohki K, Nishimura R, Hanada R, Igarashi T, Hayashi Y, Ogawa S
    • Journal Title

      Cancer Sci

      Volume: 102 Pages: 1645-1650

    • DOI

      doi: 10.1111/j.1349-7006.2011.01995.x

    • Peer Reviewed
  • [Journal Article] CBL mutation in childhood therapy-related leukemia2011

    • Author(s)
      Shiba N, Taki T, Park MJ, Nagasawa M, Kanazawa T, Takita J, Ohnishi H, Sotomatsu M, Arakawa H, Hayashi Y
    • Journal Title

      Leukemia

      Volume: 25 Pages: 1356-1358

    • DOI

      doi: 10.1038/leu.2011.75.

    • Peer Reviewed
  • [Journal Article] Chromosome abnormalities in advanced stage T-cell lymphoblastic lymphoma of children and adolescents: a report from Japanese Paediatric Leukaemia/Lymphoma Study Group (JPLSG) and review of the literature2011

    • Author(s)
      Sekimizu M, Sunami S, Nakazawa A, Hayashi Y, Okimoto Y, Saito AM, Horibe K, Tsurusawa M, Mori T
    • Journal Title

      Br J Haematol

      Volume: 154 Pages: 612-617

    • DOI

      doi:10.1111/j.1365-2141.2011.08788.x.

    • Peer Reviewed
  • [Journal Article] IDH1 and IDH2 mutations are rare in pediatric myeloid malignancies2011

    • Author(s)
      Oki K, Takita J, Hiwatari M, Nishimura R, Sanada M, Okubo J, Adachi M, Sotomatsu M, Kikuchi A, Igarashi T, Hayashi Y, Ogawa S
    • Journal Title

      Leukemia

      Volume: 25 Pages: 382-384

    • DOI

      doi: 10.1038/leu.2010.307

    • Peer Reviewed
  • [Journal Article] Oncogenic mutations of ALK in neuroblastoma2011

    • Author(s)
      Ogawa S, Takita J, Sanada M, Hayashi Y
    • Journal Title

      Cancer Science

      Volume: 102 Pages: 302-308

    • DOI

      doi: 10.1111/j.1349-7006. 2010.01825.x.

    • Peer Reviewed
  • [Journal Article] FLT3-internal tandem duplication, CD56 expression, and obstructive jaundice due to granulocytic sarcoma at relapse in a pediatric patient with t(8;21) acute myeloid leukemia2010

    • Author(s)
      Kawamura M, Kaku H, Ito T, Funata N, Taki T, Shimada A, Hayashi Y
    • Journal Title

      Cancer Genet Cytogenet

      Volume: 203 Pages: 292-296

    • DOI

      doi: 10.1016/j.cancergencyto.2010.07.130

    • Peer Reviewed
  • [Journal Article] Prominent eosinophilia but less eosinophil activation in a patient with Omenn syndrome2010

    • Author(s)
      Seki M, Kimura H, Mori A, Shimada A, Yamada Y, Maruyama K, Hayashi Y, Agematsu K, Morio T, Yachie A, Kato M
    • Journal Title

      Pediatr Int

      Volume: 52 Pages: e196-199

    • DOI

      doi: 10.1111/j.1442-200X.2010.03135.x

    • Peer Reviewed
  • [Journal Article] High frequencies of simultaneous FLT3-ITD, WT1 and KIT mutations in hematological malignancies with NUP98-fusion genes2010

    • Author(s)
      Taketani T, Taki T, Nakamura T, Kobayashi Y, Ito E, Fukuda S, Yamaguchi S, Hayashi Y
    • Journal Title

      Leukemia

      Volume: 24 Pages: 1975-1977

    • DOI

      doi: 10.1038/leu.2010.207

    • Peer Reviewed
  • [Journal Article] NOTCH1 mutation in a female with myeloid/NK cell precursor acute leukemia2010

    • Author(s)
      Shiba N, Kanazawa T, Park MJ, Okuno H, Tamura K, Tsukada S, Hayashi Y, Arakawa H
    • Journal Title

      Pediatr Blood Cancer

      Volume: 55 Pages: 1406-1409

    • DOI

      doi: 10.1002/pbc.22758

    • Peer Reviewed
  • [Journal Article] Down syndrome and GATA1 mutations in transient abnormal myeloproliferative disorder: mutation classes correlate with progression to myeloid leukemia2010

    • Author(s)
      Kanezaki R, Toki T, Terui K, Xu G, Wang R, Shimada A, Hama A, Kanegane H, Kawakami K, Endo M, Hasegawa D, Kogawa K, Adachi S, Ikeda Y, Iwamoto S, Taga T, Kosaka Y, Kojima S, Hayashi Y, Ito E
    • Journal Title

      Blood

      Volume: 116 Pages: 4631-4638

    • DOI

      doi: 10.1182/ blood-2010-05-282426

    • Peer Reviewed
  • [Journal Article] Expression of ADAMTS4 in Ewing's sarcoma2010

    • Author(s)
      Minobe K, Ono R, Matsumine A, Shibata-Minoshima F, Izawa K, Oki T, Kitaura J, Iino T, Takita J, Iwamoto S, Hori H, Komada Y, Uchida A, Hayashi Y, Kitamura T, Nosaka T
    • Journal Title

      Int J Oncol

      Volume: 37 Pages: 569-581

    • Peer Reviewed
  • [Journal Article] Prognostic significance of the BAALC isoform pattern and CEBPA mutations in pediatric acute myeloid leukemia with normal karyotype: a study by the Japanese Childhood AML Cooperative Study Group2010

    • Author(s)
      Mizushima Y, Taki T, Shimada A, Yui Y, Hiraumi Y, Matsubara H, Watanabe M, Watanabe K, Kamitsuji Y, Hayashi Y, Tsukimoto I, Kobayashi R, Horibe K, Tawa A, Nakahata T, Adachi S
    • Journal Title

      Int J Hematol

      Volume: 91 Pages: 831-837

    • DOI

      doi: 10.1007/s12185-010-0585-x

    • Peer Reviewed
  • [Journal Article] AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model2010

    • Author(s)
      Komeno Y, Kitaura J, Watanabe-Okochi N, Kato N, Oki T, Nakahara F, Harada Y, Harada H, Shinkura R, Nagaoka H, Hayashi Y, Honjo T, Kitamura T
    • Journal Title

      Leukemia

      Volume: 24 Pages: 1018-1024

    • DOI

      doi:10.1038/leu.2010.40

    • Peer Reviewed
  • [Journal Article] Tokyo Children's Cancer Study Group. Long-term results of Tokyo Children's Cancer Study Group trials for childhood acute lymphoblastic leukemialeukemia, 1984-19992010

    • Author(s)
      Tsuchida M, Ohara A, Manabe A, Kumagai M, Shimada H, Kikuchi A, Mori T, Saito M, Akiyama M, Fukushima T, Koike K, Shiobara M, Ogawa C, Kanazawa T, Noguchi Y, Oota S, Okimoto Y, Yabe H, Kajiwara M, Tomizawa D, Ko K, Sugita K, Kaneko T, Maeda M, Inukai T, Goto H, Takahashi H, Isoyama K, Hayashi Y, Hosoya R, Hanada R
    • Journal Title

      Leukemia

      Volume: 24 Pages: 383-396

    • DOI

      doi: 10.1038/leu.2009.260

    • Peer Reviewed
  • [Journal Article] CBL mutations in juvenile myelomonocytic leukemia and pediatric myelodysplastic syndrome2010

    • Author(s)
      Shiba N, Kato M, Park MJ, Sanada M, Ito E, Fukushima K, Sako M, Arakawa H, Ogawa S, Hayashi Y
    • Journal Title

      Leukemia

      Volume: 24 Pages: 1090-1092

    • DOI

      doi: 10.1038/leu.2010.49

    • Peer Reviewed
  • [Presentation] 次世代シーケンサとSNPアレイを用いた横紋筋肉腫3例における初発/再発・転移巣の比較2012

    • Author(s)
      西村力,林泰秀
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-12-02
  • [Presentation] 神経芽腫における網羅的メチル化解析2012

    • Author(s)
      関正史,林泰秀
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-11-30
  • [Presentation] 神経芽腫におけるエピジェネティック関連遺伝子の網羅的ゲノム解析2012

    • Author(s)
      星野諭子,林泰秀
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-11-30
  • [Presentation] 先端的ゲノム解析技術を用いた胸膜肺芽腫における発症分子機構の解明2012

    • Author(s)
      関正史,林泰秀
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-11-30
  • [Presentation] 次世代シークエンサーを用いたユーイング肉腫発生の分子生物学的検討2012

    • Author(s)
      樋渡光輝, 林泰秀
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-21
  • [Presentation] SNPアレイとエクソーム解析を用いた横紋筋肉腫の初発・再発/転移巣のクローン比較2012

    • Author(s)
      西村力, 林泰秀
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-21
  • [Presentation] 次世代シーケンサーによる再発肺芽腫のエクソーム解析2012

    • Author(s)
      関正史, 林泰秀
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-21
  • [Presentation] 神経芽腫におけるエピジェネティック関連遺伝子の網羅的ゲノム解析2012

    • Author(s)
      星野諭子, 林泰秀
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-20
  • [Presentation] 先端的ゲノムスキャニングを用いた難治性小児固形腫瘍における標的分子の探索2012

    • Author(s)
      滝田順子, 林泰秀
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2012-04-21
  • [Presentation] 次世代シークエンサーを用いた神経芽腫のエクソーム解析2012

    • Author(s)
      西村力, 林泰秀
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2012-04-21
  • [Presentation] 次世代シークエンサーを用いたEwing肉腫のエクソーム解析2012

    • Author(s)
      大久保純, 林泰秀
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2012-04-21
  • [Presentation] 小児固形腫瘍におけるIDH 1/2変異の解析2011

    • Author(s)
      大久保淳,大木健太郎,林泰秀
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Year and Date
      2011-11-27
  • [Presentation] 小児固形腫瘍組織におけるI型インスリン様増殖因子受容体(IGF-1R)2011

    • Author(s)
      若井公子,大木健太郎,朴明子,外松学,林泰秀
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Year and Date
      2011-11-27
  • [Presentation] 次世代シークエンサによる神経芽腫のエクソーム解析2011

    • Author(s)
      西村力,林泰秀
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Year and Date
      2011-11-26
  • [Presentation] 次世代シーケンサーによる神経芽腫のエクソーム解析2011

    • Author(s)
      西村力,林泰秀
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
  • [Presentation] 小児固形腫瘍におけるIDH変異の解析2011

    • Author(s)
      大久保淳,大木健太郎,林泰秀
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
  • [Presentation] 神経芽腫における部分欠損型ALKの造腫瘍性に関する検討2011

    • Author(s)
      大久保淳,大木健太郎,林泰秀
    • Organizer
      第114回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-08-14
  • [Presentation] 高密度SNPアレイを用いた胸膜肺芽腫における網羅的ゲノム解析2011

    • Author(s)
      大久保淳,大木健太郎,林泰秀
    • Organizer
      第114回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-08-14
  • [Presentation] 革新的ゲノム解析技術を用いた難治性小児固形腫瘍における発症分子機構の解明2011

    • Author(s)
      滝田順子,林泰秀
    • Organizer
      第114回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-08-12
  • [Presentation] 神経芽腫における全エクソン領域のシークエンス解析2011

    • Author(s)
      安達正時,大木健太郎,林泰秀
    • Organizer
      第114回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-08-12
  • [Presentation] Effects of selective ALK inhibitors to neuroblastoma2010

    • Author(s)
      Takita J, Hayashi Y
    • Organizer
      Advances in Neuroblastoma Research
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      20100621-24
  • [Presentation] Aberrant activation of ALK kinase by a short form ALK protein in neuroblastoma2010

    • Author(s)
      Okubo J, Hayashi Y
    • Organizer
      Advances in Neuroblastoma Research
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      20100621-24
  • [Presentation] 小児固形腫瘍におけるNOTCHシグナルの検討;発現様式と遺伝子変異の解析2010

    • Author(s)
      安達正時, 大木健太郎, 林泰秀
    • Organizer
      第52回日本小児血液学会総会・第26回日本小児がん学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-18
  • [Presentation] 胸膜肺芽腫における網羅的ゲノム解析2010

    • Author(s)
      大久保淳, 大木健太郎, 林泰秀
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
  • [Presentation] 小児固形腫瘍におけるALK遺伝子の関与2010

    • Author(s)
      滝田順子, 大木健太郎, 林 泰秀
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
  • [Presentation] 小児固形腫瘍におけるALK阻害剤の効果に関する検討2010

    • Author(s)
      大久保淳,大木健太郎,林泰秀
    • Organizer
      第113回日本小児科学会学術集会
    • Place of Presentation
      岩手
    • Year and Date
      2010-04-24
  • [Presentation] ALK gene aberrations in pediatric solid tumors2010

    • Author(s)
      Takita J, Ohki K, Hayashi Y
    • Organizer
      The 6th Congress of Asian Society for Pediatric Research & 51st Annual Meeting of Taiwan Pediatric Association
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2010-04-15
  • [Presentation] High resolution copy number analysis of Ewing sarcoma family of tumors using high-density SNP-genotyping microarrays2010

    • Author(s)
      Nishimura R, Ohki K, Hayashi Y
    • Organizer
      The 6th Congress of Asian Society for Pediatric Research & 51st Annual Meeting of Taiwan Pediatric Association
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2010-04-15

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Published: 2014-08-29   Modified: 2014-12-03  

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