2012 Fiscal Year Final Research Report
Establishment of in situ functional neuroimaging for social Behavior and its application to psychiatry
| Project/Area Number |
22659209
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Gunma University |
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Principal Investigator |
FUKUDA Masato 群馬大学, 大学院・医学系研究科, 准教授 (20221533)
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| Co-Investigator(Kenkyū-buntansha) |
MIKUNI Masahiko 群馬大学, 大学院・医学系研究科, 教授 (00125353)
KAMEYAMA Masaki 群馬大学, 大学院・医学系研究科, 助教 (00455982)
TAKEI Yuichi 群馬大学, 医学部, 助教 (30455985)
UEHARA Toru 群馬大学, 健康支援総合センター, 准教授 (60303145)
NARITA Kosuke 群馬大学, 医学部, 講師 (70345677)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 統合失調症 / 気分障害 / 対人関係 / 近赤外線スペクトロスコピィ / 前頭極 |
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| Research Abstract |
Brain substrates of social behavior were investigated using near-infrared spectroscopy (NIRS) just during the conversation. Frontal and temporal activations during the conversation were correlated positively with cooperativeness assessed with the NEO-PI-R and negatively with autistic trait assessed with the autism quotient (AQ) in healthy subjects, and were also negatively correlated with negative symptoms assessed with the PANSS in schizophrenia patients. These results demonstrate successful establishment of functional neuroimaging examination just during social behaviors, which can be called as "in situ neuroimaging".
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Research Products
(33 results)
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[Journal Article] Associations among parenting experiences during childhood and adolescence, hypothalamus-pituitary-adrenal axis hypoactivity, and hippocampal gray matter volume reduction in young adults2012
Author(s)
Narita K, Fujihara K, Takei Y, Suda M, Aoyama Y, Uehara T, Majima T, Kosaka H, Amanuma M, Fukuda M, Mikuni M
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Journal Title
Hum Brain Mapp
Volume: 33
Pages: 2211-2223
DOI
Peer Reviewed
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[Journal Article] Different hemodynamic response patterns in the prefrontal cortical sub-regions according to the clinical stages of psychosis2011
Author(s)
Koike S, Takizawa R, Nishimura Y, Takano Y, Takayanagi Y, Kinou M, Araki T, Harima H, Fukuda M, Okazaki Y, Kasai K
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Journal Title
Schizophr Res
Volume: 132
Pages: 54-61
DOI
Peer Reviewed
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[Remarks] 信濃毎日新聞:問診主体の診断を補助-前頭葉の血流量を調べる検査(シリーズ:現代を映すこころの病第2章「従来型」うつ病の今(1))2012.6.8.
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[Remarks] NHK総合放送:番組・NHKスペシャル「ここまで来た!うつ病治療」2012.2.12.
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[Remarks] 日本経済新聞:協調性のない人は「努力して」会話-脳の血液量変化で推測.2011.2.9.朝刊.
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[Remarks] Nature (This Week Editorial) : First do no harm: Simple tools to diagnose mental illness should not be offered without soundsupporting evidence. Nature 469: 132, 2011.
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[Remarks] Nature (Feature News) : Thought experiment: Japanese hospitals are using near-infrared imaging to help diagnosepsychiatric disorders. But critics are not sure the technique is ready for the clinic. Nature469:148-149 (by David Cyranoski, Nature'sAsia-Pacific correspondent).
