2012 Fiscal Year Final Research Report
Brain functional imaging study of possible effects of substance Preceptor antagonist on alcohol craving
| Project/Area Number |
22659212
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Nippon Medical School |
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Principal Investigator |
OKUBO Yoshiro 日本医科大学, 大学院・医学研究科, 教授 (20213663)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Hidenori 日本医科大学, 大学院・医学研究科, 教授 (30221328)
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| Project Period (FY) |
2010 – 2012
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| Keywords | アルコール依存症 / サブスタンス P 受容体 / 脳機能画像 |
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| Research Abstract |
Neurokinin-1 (NK1) receptor, the cognate receptor for substance P (SP), is highly expressed in the nucleus accumbens (NAc) and has been hypothesized to have a role in positive reward processing in the NAc in humans. Therefore, we conducted a functional MRI (fMRI) study to assess the effects of an NK1 receptor antagonist on human reward processing. Healthy adults participated in series of an fMRI study, taking either a placebo or the NK1 receptor antagonist aprepitant. fMRI showed significant decrease in blood oxygenation-level-dependent signals in the NAc during gain anticipation with the aprepitant treatment compared to the placebo treatment. These results suggest that SP/NK1 receptor system is involved in reword processing and plays a role in accentuating positive valence or alcohol craving in the reward circuit.
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Research Products
(29 results)
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[Journal Article] Honesty mediates the relationship between serotonin and reaction to unfairness2012
Author(s)
Takahashi H, Takano H, Camerer CF, Ideno T, Okubo S, Matsui H, Tamari Y, Takemura K, Arakawa R, Kodaka F, Yamada M, Eguchi Y, Murai T, Okubo Y, Kato M, Ito H, Suhara T.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 109(11)
Pages: 4281-4
DOI
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