2012 Fiscal Year Final Research Report
Aimed at clinical application, functional analysis of a novelmolecule "SHATI" by proteomics-like technique.
| Project/Area Number |
22659213
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Meijo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TORIUMI Kazuya 東京都医学総合研究所, 固有研究員 (10549421)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 精神薬理学 |
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| Research Abstract |
To reveal function of a novel drug dependence-related molecule “Shati,” we exploredSHATI-binding proteins using pull-down assays and identified a number of components of the adaptorprotein (AP)-2 complex, which is a multimeric protein localized to the plasma membrane that functionsto internalize receptors during clathrin-mediated endocytosis. We demonstrated a novel function ofSHATI that promotes the localization of DA receptors to the cell surface via an association with theadaptor protein (AP)-2 complex, thereby inhibiting METH dependence. Furthermore, we show thatSHATI is both associated and colocalized with microtubules in neurons, and regulated neuriteelongation.
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[Journal Article] Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ.2012
Author(s)
Shin EJ, Duong CX, Nguyen XK, Li Z, Bing G, Bach JH, Park DH, Nakayama K, Ali SF, Kanthasamy AG, Cadet JL, Nabeshima T, Kim HC
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Journal Title
Behav Brain Res.
Volume: 232
Pages: 98-113
Peer Reviewed
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[Journal Article] Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits.2010
Author(s)
Niwa M, Kamiya A, Murai R, Kubo K, Gruber AJ, Tomita K, Lu L, Tomisato S, Jaaro-Peled H, Seshadri S, Hiyama H, Huang B, Kohda K, Noda Y, O'Donnell P, Nakajima K, Sawa A, Nabeshima T.
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Journal Title
Neuron
Volume: 65
Pages: 1-10
Peer Reviewed
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