Cell tracking technique of iPS cells and clinical application using PET and MRI

2011 Fiscal Year Final Research Report

• Project/Area Number: 22659217
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Kyoto College of Medical Science (2011); Gunma University (2010)
• Principal Investigator: ENDO Keigo 京都医療科学大学, 医療科学部, 学長 (10115800)
• Research Collaborator: HANAOKA Hirofumi 千葉大学, 助教 (50361390)
• Project Period (FY): 2010 – 2011
• Keywords: 放射線 / 癌 / 画像 / iPS細胞 / PET / MRI

Research Abstract

iPS cells were successfully labeled with radioisotopes such as^<18> F,^<64> Cu in a good yield. Biodistribution of radiolabeled iPS cells in mice were clearly visualized using PET, indicating the potential of PET imaging of iPS cells. On the other hands, iPS cells labeled with SPIO(contrast agent for MRI), injected into the tail veins of mice, could not be imaged with MRI due to the susceptibility effect of air in the lung.

Research Products

• [Journal Article] In vivo therapeutic effect of CDH3/P-cadherin-targeting radioimmunotherapy (2012)
  • Author(s): Yoshioka H, Yamamoto S, Hanaoka H, Iida Y, Paudyal P, Higuchi T, Tominaga H, Oriuchi N, Nakagawa H, Shiba Y, Yoshida K, Osawa R, Katagiri T, Tsunoda T, Nakamura Y, Endo K
  • Journal Title: Cancer Immunol Immunother
  • DOI: DOI:10.1007/s00262-011-1186-0
  • Peer Reviewed
• [Journal Article] Predicting cetuximab accumulation in KRAS wild-type and KRAS mutant colorectal cancer using^<64> Cu-labeled cetuximab positron emission tomography (2011)
  • Author(s): Achmad A, Hanaoka H, Yoshioka H, Yamamoto S, Tominaga H, Araki T, Ohshima Y, Oriuchi N, Endo K
  • Journal Title: Cancer Sci Volume: 103 Pages: 600-605
  • DOI: DOI:10.1111/j.1349-7006.2011.02166.x
  • Peer Reviewed
• [Journal Article] Preparation and biological evaluation of 3-[76Br] bromo-α-methyl-L-tyrosine, a novel tyrosine analog for positron emission tomography imaging of tumors (2011)
  • Author(s): Ohshima Y, Hanaoka H, Watanabe S, Sugo Y, Watanabe S, Tominaga H, Oriuchi N, Endo K, Ishioka NS
  • Journal Title: Nucl Med Biol Volume: 38 Pages: 857-865
  • DOI: DOI:10.1016/j.nucmedbio.2011.02.001
  • Peer Reviewed
• [Journal Article] Clinical significance of 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography for the assessment of 131I-metaiodobenzylguanidine therapy in malignant phaeochromocytoma (2011)
  • Author(s): Nakazawa A, Higuchi T, Oriuchi N, Arisaka Y, Endo K
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 38 Pages: 1869-1875
  • DOI: DOI:10.1007/s00259-011-1872-3
  • Peer Reviewed
• [Journal Article] Feasibility of measuring human pancreatic perfusion in vivo using imaging techniques (2011)
  • Author(s): Tsushima Y, Miyazaki M, Taketomi-Takahashi A, Endo K
  • Journal Title: Pancreas Volume: 40 Pages: 747-752
  • DOI: DOI:10.1097/MPA.obo13e318215ac22
  • Peer Reviewed
• [Journal Article] Positron emission tomography imaging and biodistribution of vascular endothelial growth factor with 64Cu-labeled bevacizumab in colorectal cancer xenografts (2011)
  • Author(s): Paudyal B, Paudyal P, Oriuchi N, Hanaoka H, Tominaga H, Endo K
  • Journal Title: Cancer Sci Volume: 102 Pages: 117-121
  • DOI: DOI:10.1111/j.1349-7006.2010.01763.x
  • Peer Reviewed