2012 Fiscal Year Final Research Report
Pathogenesis of shaggy aorta syndrome
| Project/Area Number |
22659232
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
YOSHIMURA Koichi 山口大学, 大学院・医学系研究科, 准教授(特命) (00322248)
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| Co-Investigator(Kenkyū-buntansha) |
AOKI Hiroki 久留米大学, 循環器病研究所, 教授 (60322244)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 大動脈 |
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| Research Abstract |
Shaggy aorta syndrome is a difficult-to-treat disease causing peripheral, renal and visceral ischemia caused by multiple cholesterol emboli from the aorta. The mechanisms underlying the development of shaggy aorta remain largely unknown. In this study, we examined the role of ASC/Caspase-1 in the development of shaggy aorta with cholesterol crystals.
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[Journal Article] Macrophage-derived Angiopoietin- like Protein 2 Accelerates the Development of Abdominal Aortic Aneurysm.2012
Author(s)
Tazume H, Miyata K, Tian Z, Endo M, Horiguchi H, Takahashi O, Horio E, Tsukano H, Kadomatsu T, Nakashima Y, Kunitomo R, Kaneko Y, Moriyama S, Sakaguchi H, Okamoto K, Hara M, Yoshinaga T, Yoshimura K, Aoki H, Araki K, Hao H, Kawasuji M, Oike Y.
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 32(6)
Pages: 1400-1409
DOI
Peer Reviewed
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[Journal Article] Inhibition of Development of Abdominal Aortic Aneurysm by Glycolysis Restriction2012
Author(s)
Tsuruda T, Hatakeyama K, Nagamachi S, Sekita Y, Sakamoto S, Endo GJ, Nishimura M, Matsuyama M, Yoshimura K, Sato Y, Onitsuka T, Imamura T, Asada Y, Kitamura K
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 32(6)
Pages: 1410-1417
DOI
Peer Reviewed
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[Journal Article] C-Jun N-terminal kinase induces axonal degeneration and limits motor recovery after spinal cord injury in mice2011
Author(s)
Yoshimura, K., Ueno, M., Lee, S., Nakamura, Y., Sato, A., Yoshimura, K., Kishima, H., Yoshimine, T. and Yamashita, T
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Journal Title
Neurosci. Res
Volume: 71(3)
Pages: 266-277
DOI
Peer Reviewed
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[Journal Article] Tenascin-C is expressed in abdominal aortic aneurysm tissue with active degradation process2011
Author(s)
Kimura T, Yoshimura K, Aoki H, Imanaka-Yoshida K, Yoshida T, Ikeda Y, Morikage N, Endo H, Hamano K, Imaizumi T, Hiroe M, Aonuma K, Matsuzaki M
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Journal Title
Pathol Int
Volume: 61
Pages: 559-564
DOI
Peer Reviewed
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[Journal Article] Resveratrol Prevents the Development of Abdominal Aortic Aneurysm through Attenuation of Inflammation, Oxidative Stress, and Neovascularization2011
Author(s)
Kaneko H, Anzai T, Morisawa M, Kohno T, Nagai T, Anzai A, Takahashi T, Shimoda M, Sasaki A, Maekawa Y, Yoshimura K, Aoki H, Tsubota K, Yoshikawa T, Okada Y, Ogawa S, Fukuda K
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Journal Title
Atherosclerosis
Volume: 217(2)
Pages: 350-357
DOI
Peer Reviewed
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[Journal Article] Role of vascular endothelial growth factor-A in development of abdominal aortic aneurysm2011
Author(s)
Kaneko H, Anzai T, Takahashi T, Kohno T, Shimoda M, Sasaki A, Shimizu H, Nagai T, Maekawa Y, Yoshimura K, Aoki H, Yoshikawa T, Okada Y, Yozu R, Ogawa S, Fukuda K
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Journal Title
Cardiovasc Res
Volume: 91(2)
Pages: 358-367
DOI
Peer Reviewed
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