2011 Fiscal Year Final Research Report
Development of the tools for organ stress and its surgical application
| Project/Area Number |
22659237
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
TODO Satoru 北海道大学, 大学院・医学研究科, 特任教授 (60136463)
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| Co-Investigator(Kenkyū-buntansha) |
OZAKI Michitaka 北海道大学, 大学院・保健科学研究院, 教授 (80256510)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 生体イメージング / 脂肪肝 / 肝ストレス / メタボリック症候群 / 肝障害 / 肝再生 |
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| Research Abstract |
Steatotic liver, very sensitive to various surgical procedures, is associated with post-operative liver failure, impaired regeneration, post-operative infection and sepsis. In the present study, we analyzed whether the surgical stress affects the post-operativeliver function, injury and regeneration of steatotic liver by newly developed optic probes for bio-imaging. We evaluated mouse liver continuously and non-invasively and analyzed the underlying mechanism of post-operative liver injury and impaired regeneration.
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Research Products
(17 results)
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[Journal Article] Stevens-Johnson syndrome/toxic epidermal necrolysis mouse model generated by using PBMCs and the skin of patients2013
Author(s)
Saito N, Yoshioka N, Abe R, Qiao H, Fujita Y, Hoshina D, Suto A, Kase S, Kitaichi N, Ozaki M, Shimizu H.J
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Journal Title
Allergy Clin Immunol
Volume: 131(2)
Pages: 434-41
Peer Reviewed
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[Journal Article] Immunosuppressive effects of DTCM-G, a novel inhibitor of the mTOR downstreamsignaling pathway2013
Author(s)
Shibasaki S, Yamashita K, Goto R, Wakayama K, Tsunetoshi Y, Zaitsu M, Igarashi R, Haga S, Ozaki M, Umezawa K, Todo S
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Journal Title
Transplantation
Volume: 95(4)
Pages: 542-50
Peer Reviewed
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