2012 Fiscal Year Final Research Report
Development of a implantable medical device with the self-curable NC-hydrogel.
| Project/Area Number |
22659255
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
MIZUNO Toshihide 独立行政法人国立循環器病研究センター, 研究所, 室長 (40426515)
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| Co-Investigator(Renkei-kenkyūsha) |
HARAGUCHI Kazutoshi 独立行政法人国立循環器病研究センター, 研究所, 部長 (10373391)
TSUKIYA Tomonori 独立行政法人国立循環器病研究センター, 研究所・人工臓器部, 室長 (00311449)
HONMA Akihiko 東京電機大学, 工学部, 教授 (20287428)
TAKEWA Yoshiaki 独立行政法人国立循環器病研究センター, 研究所・人工臓器部, 室長 (20332405)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ヒドロゲル / 人工血管 / 人工弁 |
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| Research Abstract |
Recently, the demand of wet soft materials for bio-related applications has been increasing. Thus far, we have developed a novel nanocomposite hydrogel (NC gel) with extraordinary mechanical, optical, and swelling/deswelling properties by extending the concept of organic/inorganic NCs to soft hydrogels. In this study, we aimed to develop novel NC gel materials and devices for biomedical applications, such as an implantable material with long-term durability, by improving the functions of the NC gel (e.g. extensibility, absorption of plasma, biological safety, nonconcrescence, and asepsis) and fabricating it in various forms. We succeeded in improving its mechanical, surface, and swelling/deswelling properties by modifying its network.
(2) With regard to the development of new devices, we used NC gel-medical materials. We concluded that NC gels comfortably were able to use as the durable implanted material while simultaneously preventing the formation of intractable granulomatous tissues. Further, we carried out an in vivo investigation of the interaction of living tissue with the NC gel by implantation in goats. We found that neither inflammation nor concrescence occurred around the NC gels.
(3) With regard to the safety and product design of medical devices, we carried out biological testing of medical devices, which involved a sensitization test, irritation test, intracutaneous test, and in vitro cytotoxicity test. We confirmed the safety of the NC gel in all these tests.
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