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2011 Fiscal Year Final Research Report

Reorganization of basal ganglia circuitry in animal model of parkinson's disease by stimulation of subthalamic nucleus

Research Project

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Project/Area Number 22659264
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionKitasato University

Principal Investigator

SAJI Makoto  北里大学, 医療衛生学部, 教授 (50114179)

Co-Investigator(Kenkyū-buntansha) TAKIYAMA Youko  北里大学, 医学部, 講師 (60265593)
SATO Sumito  北里大学, 医学部, 助教 (40266052)
Project Period (FY) 2010 – 2011
Keywords片側パーキンソン病モデル / 深部脳刺激 / 視床下核 / 運動症状改善 / NMDA受容体NR2Bアンタゴニスト / 基底核回路
Research Abstract

To test the hypothesis that STN-DBS inducesa long-lasting reconstruction of basal gangliacircuitry in parkinsonian rats mediatedby expression of LTP on synapses in the nearby nuclei, we examined whether NMDA receptor(NMDAR) subunit NR2B antagonist potentiates the alleviating after-effect of STN-DBS and lasts the improvement of motor deficits by transient STN-DBS long for hours or days.
Prior to the test for the potentiation of alleviating effect of STN-DBS by NR2B antagonist in hemi-parkinsonian rats, we first examined whether mono-therapeutic treatment with NR2B antagonist(ifenprodil) improves the motor symptoms in hemi-parkinsonian rats. As a result, in hemiparkinsonianrats, we found that ifenprodil did not cause an improvement of the deficits of motor coordination, while the drug potentiated the ameliorative effect of L-DOPAon the deficit of motor coordination whencombined with L-DOPA, suggesting the synergistic action of ifenprodil on the antiparkinsonian effect of L-DOPA. From this result, it is suggested that a combined treatment with STN-DBS and NR2B antagonist could be more effective than STN-DBS alone to improve the chronic L-DOPA-induced dyskinesias with less side-effect.

  • Research Products

    (9 results)

All 2012 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (6 results)

  • [Journal Article] Evaluation of neurotoxicity of artificial dura mater and dura mater containing a high concentration of dibutyltin in rats after intracranial implantation2012

    • Author(s)
      Tsunoda M, Ikeuchi R, Tsuji M, Inoue Y, Ito K, Katagiri H, Akita H, Saji M., Yuba T, Yamada T, Tsuchiya T, Aizawa Y
    • Journal Title

      Kitasato Med J

      Volume: 42 Pages: 67-75

    • Peer Reviewed
  • [Journal Article] Activation of the NMDA receptor involved in the alleviating after-effect of repeated stimulation of the subthalamic nucleus on motor deficits in hemiparkinsonia rats2010

    • Author(s)
      Akita H, Honda Y, Ogata M, Noda K, Saji M
    • Journal Title

      Brain Res

      Volume: 1306 Pages: 159-167

    • Peer Reviewed
  • [Journal Article] Enhanced inhibitory effects of TBT chloride on the development of F_1 rats2010

    • Author(s)
      Asakawa H, Tsunoda M, Kaido T, Hosokawa M, Sugaya C, Inouue Y, Kudo Y, Satoh T, Katagiri H, Akita H, Saji M, Wakasa M, Negish T, Tashiro T, Aizawa Y
    • Journal Title

      Arch Environ ContamTaxicol

      Volume: 58 Pages: 1065-1073

    • Peer Reviewed
  • [Presentation] The neurotoxic effects of tributylin on mele F1 rats by continuous exposurefrom the fetal stage through their developing stages2011

    • Author(s)
      Ikeuchi R, Kido T, Sugaya C, Tsunoda M, Katagiri H, Uchimura A, Akita H, Saji M, Aizawa Y
    • Organizer
      50th annual meeting for societyof toxicology
    • Place of Presentation
      Washington DC
    • Year and Date
      20110306-10
  • [Presentation] Switching from learning behavior to thigmotaxis in mater maze induced by in vivo delivery of antibody against AMPA receptor GluA1-C terminus via HVJ-E vector into hippocampal neurons in rats2011

    • Author(s)
      Saji M, Shimizu D, Ogata M, Noda K, Suzuki N, Akita H
    • Organizer
      41st annual meeting of society for neuroscience
    • Place of Presentation
      Washington DC
    • Year and Date
      2011-11-15
  • [Presentation] Loss of motivation for learning in water maze by in vivo delivery of antibody to AMPA receptor GluR1-C terminus via HVJ-E vector into hippocampal CA1 neurons in rats2011

    • Author(s)
      Saji M, Ogata M, Noda K, Suzuki N, Akita H
    • Organizer
      IBRO world congress of neuroscience
    • Place of Presentation
      Firenze, Italy
    • Year and Date
      2011-07-12
  • [Presentation] NMDA receotpr-mediated plasticity in the alleviating after-effect of subthalamic stimulation on akinetic motor deficit in rat models of Parkinson's disease2010

    • Author(s)
      Akita H, Honda Y, Ogata, Noda K, Saji M
    • Organizer
      40th annual meeting of society for neuroscience
    • Place of Presentation
      San Diego
    • Year and Date
      2010-11-15
  • [Presentation] Paclitaxel-induced hyperalgesia modulates NR1 receptor expression in the frontal cortex and negative affective component of pain in rats2010

    • Author(s)
      Noda K, Akita H, Ogata M, Saji M
    • Organizer
      13th world congress on pain
    • Place of Presentation
      Montreal
    • Year and Date
      2010-08-30
  • [Presentation] Evaluation of TBT neurotoxicity in developing male F1 rats by open field tests2010

    • Author(s)
      Tsunoda M, Kado T, Ikeuchi R, Hosokawa M, Sugaya C, Inoue Y, Kudo Y, Akita H, Saji M, Takeuchi Y, Yoshioka R, Tashiro T, Aizawa Y
    • Organizer
      49th Annual Meeting for Society of Toxicology
    • Place of Presentation
      Salt Lake City
    • Year and Date
      2010-03-01

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Published: 2013-07-31  

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