Research of molecular mechanisms regulating responsiveness to chondrogenic cytokines by intracellular trafficking protein SNX

2011 Fiscal Year Final Research Report

• Project/Area Number: 22659265
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: TAKESHITA Katsushi 東京大学, 医学部附属病院, 准教授 (30262009)
• Co-Investigator(Kenkyū-buntansha): NAKAGAWA Takumi 東京大学, 医学部附属病院, 講師 (90338385) ; HIROTA Jinso 東京大学, 医学部附属病院, 助教 (30570733)
• Project Period (FY): 2010 – 2011
• Keywords: 骨 / 軟骨代謝学

Research Abstract

SNX19, a member of the SNX family of intracellular trafficking proteins, was highly expressed in chondrocytes through their differentiation. SNX19 enhanced the production of cartilage matrix like Col2a1 ; however, the molecular mechanism underlying the enhancement was still unrevealed

Research Products

• [Journal Article] Neurological recovery after posterior decompression surgery for anterior dural compression in paralytic spinal metastasis (2012)
  • Author(s): Kato S, Takeshita K, et al
  • Journal Title: Arch Orthop Trauma Surg. E-pub
  • Peer Reviewed
• [Journal Article] The normative score and the cut-off value of the Oswestry Disability Index(ODI) (2012)
  • Author(s): Tonosu J, Takeshita K, et al
  • Journal Title: Eur Spine J. E-pub
  • Peer Reviewed
• [Journal Article] Mortality and morbidity in dialysis-dependent patients undergoing spinal surgery : analysis of a national administrative database in Japan (2012)
  • Author(s): Chikuda H, Yasunaga H, Horiguchi H, Takeshita K, et al
  • Journal Title: J Bone Joint Surg Am Volume: 94 Pages: 433-8
  • Peer Reviewed
• [Journal Article] C/EBPβand RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2αas the inducer in chondrocytes (2012)
  • Author(s): Hirata M, Nakagawa T, et al
  • Journal Title: Hum Mol Genet Volume: 21 Pages: 1111
  • Peer Reviewed
• [Journal Article] Lack of a chondroprotective effect of cyclooxygenase 2 inhibition in a surgically induced model of osteoarthritis in mice (2012)
  • Author(s): Fukai A, Nakagawa T, et al
  • Journal Title: Arthritis Rheum Volume: 64 Pages: 198
  • Peer Reviewed
• [Journal Article] Immunohistological analysis of extracted anterior cruciate ligament graft impinged against posterior cruciate ligament (2011)
  • Author(s): Kato S, Fukai A, Takeda H, Taketomi S, Nakayama S, Hirota J, Nakajima K, Nakamura K, Nakagawa T
  • Journal Title: Sports Med Arthrosc Rehabil Ther Technol Volume: 3 Pages: 26
  • Peer Reviewed
• [Journal Article] Osteochondral autograft for medial femoral condyle chondral lesions in a patient with multiple epiphyseal dysplasia : long-term result (2011)
  • Author(s): Taketomi S, Hiraoka H, Nakagawa T, Miyamoto Y, Kuribayashi S, Fukuda A, Takeda H, Fukai A, Hirota J, Nakajima K, Haga N, Nakamura K
  • Journal Title: J Orthop Sci
  • Peer Reviewed
• [Journal Article] Use of Doppler ultrasonography to detect an elusive communication of a spinal extradural arachnoid cyst (2011)
  • Author(s): Kanetaka M, Sugita S, Chikuda H, Takeshita K, et al
  • Journal Title: J Clin Neurosci Pages: 18863-4
  • Peer Reviewed
• [Journal Article] Prevention and management of knee osteoarthritis and knee cartilage injury in sports (2011)
  • Author(s): Takeda H, Nakagawa T, Nakamura K, Engebretsen L
  • Journal Title: Br J Sports Med Volume: 45 Pages: 304-99
  • Peer Reviewed
• [Journal Article] Is a right pedicle screw always away from the aorta in scoliosis? (2011)
  • Author(s): Takeshita K, et al
  • Journal Title: Spine(Phila Pa 1976) Volume: 36 Pages: E1519-24
  • Peer Reviewed
• [Journal Article] Acute cervical spinal cord injury complicated by preexisting ossification of the posterior longitudinal ligament : a multicenter study (2011)
  • Author(s): Chikuda H, Seichi A, Takeshita K, et al
  • Journal Title: Spine(Phila Pa 1976) Volume: 36 Pages: 1453-8
  • Peer Reviewed
• [Journal Article] Aorta movement in patients with scoliosis after posterior surgery (2010)
  • Author(s): Takeshita K, et al
  • Journal Title: Spine(Phila Pa 1976) Volume: 35 Pages: E1571-6
  • Peer Reviewed
• [Journal Article] Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development (2010)
  • Author(s): Saito T, Nakagawa T, et al
  • Journal Title: Nat Med Volume: 16 Pages: 678
  • Peer Reviewed
• [Presentation] Predictability of surgical correction of scoliosis by supine, side-bending fulcrum and traction radiographs (2010)
  • Author(s): Takeshita K, et al
  • Organizer: 17th International Meeting on Advance Spine Techniques
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2010-07-21
• [Remarks]
  • URL: http://www.u-tokyo-ortho.jp/