2011 Fiscal Year Final Research Report
Development of novel osteoanabolic agents by selective inhibition of Gq signal in osteoblasts
| Project/Area Number |
22659267
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OGATA Naoshi 東京大学, 医学部附属病院, 講師 (10361495)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Taku 東京大学, 医学部附属病院, 特任准教授 (30456107)
MIRURA Toshiki 東京大学, 医学部附属病院, 講師 (20376479)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 骨・軟骨代謝学 |
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| Research Abstract |
We have analyzed whether RGS-2 overexpression in osteoblasts will suppress Gq signal which is known to inhibit osteoblast differentiation leading enhancement of PTH osteoanabolic effect. RGS-2 suppressed Gq singnal and inhibited osteoblast differentiation. We have also screened small compounds that would suppress Gq signal, like RGS-2, in osteoblasts using our small compound library consisted of 20000 compounds. However, we could not find the small compounds that suppress both Gq signal and enhance PTH effect on osteoblast differentiation.
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