2011 Fiscal Year Final Research Report
Elucidation for mechanisms of development and regeneration in tendon and ligament
| Project/Area Number |
22659278
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | National Research Institute for Child Health and Development |
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Principal Investigator |
ASAHARA Hiroshi 独立行政法人国立成育医療研究センター, システム発生・再生医学研究部, 客員研究部長 (70294460)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAKI Shigeru 独立行政法人国立成育医療研究センター, システム発生・再生医学研究部, 共同研究員 (10392490)
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| Research Collaborator |
ITO Yoshiaki 独立行政法人国立成育医療研究センター, システム発生・再生医学研究部, 共同研究員 (50511044)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 関節病学 / Mohawk / 腱 / 靭帯 |
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| Research Abstract |
Tendon and ligament are dense, fibrous connective tissues that allow for body movement. Elucidation for mechanisms of development and regeneration in these tissues is important research subject because tendon and ligament tissues heal very slowly and rarely recovers completely. We identified Mkx as a transcription factor specifically expressing in tendon and ligament. To investigate the in vivo functions of Mkx, we generated Mkx^<-/-> mice. These mice had hypoplastic tendons throughout the body. We also observed a downregulation of type I collagen in Mkx^<-/-> tendons. These data indicate that Mkx plays a critical role in tendon differentiation. We also performed the screening for upstream and downstream factors of Mkx, and identified the candidate genes. These findings will serve as a basis for understanding molecular mechanisms of tendon differentiation and may provide a therapeutic target for tendon injuries and tendon related diseases, such as Ehlers-Danlos syndrome.
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[Journal Article] The Mohawk homeobox gene is a critical regulator of tendon differentiation2010
Author(s)
Ito Y, Toriuchi N, Yoshitaka T, Ueno-Kudoh H, Sato T, Yokoyama S, Nishida K, Akimoto T, Takahashi M, Miyaki S, Asahara H
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Journal Title
Proc Natl Acad Sci U S A
Volume: Vol.107,No.23
Pages: 10538-10542
DOI
Peer Reviewed
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