2011 Fiscal Year Final Research Report
Effects of chronic morphine treatment on angiogenesis
| Project/Area Number |
22659279
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 疼痛管理学 |
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| Research Abstract |
Chronic treatment of morphine at low doses(0. 1-3 mg/kg/day) attenuated the growth of Lewis lung carcinoma(LLC) in C57BL/6 mice. However, higher dose(10mg/kg/day) of morphine does not affect LLC growth. These results suggest that effects of chronic morphine treatment on growth of LLC may be biphasic alteration.
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