2011 Fiscal Year Final Research Report
Development of new treatments of chemotherapy-induced peripheral neuropathy
| Project/Area Number |
22659285
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Shinshu University (2011)
Sapporo Medical University (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 化学療法 / 末梢神経障害 / 痛み |
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| Research Abstract |
Paclitaxel treatment is often associated with dose-limiting painful peripheral neuropathy and subsequent neuropathic pain that is resistant to standard analgesics. Our results showed that satellite cell-derived L-serine in the DRG plays an important role in paclitaxel-induced painful peripheral neuropathy. These findings may lead to novel strategies for the treatment of paclitaxel-induced painful peripheral neuropathy.
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