2011 Fiscal Year Final Research Report
Establishment of diagnosis of renal and prostate cancer by analysis of the expression of microRNAs in blood
| Project/Area Number |
22659286
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OBA Shigeyoshi 東京大学, 医学部附属病院, 助教 (80361492)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 腫瘍学 / microRNA |
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| Research Abstract |
We compared the expression of microRNAs in blood of normal control and renal carcinoma patients. The result is that 20 microRNAs were predominantly dysregulated in renal carcinoma patients. Among 20 microRNAs, 9 microRNAs were more predominantly dysregulated. By scoring the expression of 9 microRNAs, we could establish new diagnosis method with over 70%-80% sensitivity and specificity. Then we compared the expression of 9 microRNAs between new 3 normal control and 3 renal carcinoma patients. One microRNA tent to decrease in renal cell carcinoma patients.
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