2011 Fiscal Year Final Research Report
Correlation between inflammation-associated carcinogenesis and ectopic expression of activation-induced cytidine deaminase in prostatic epithelial cells
| Project/Area Number |
22659287
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
EISHI Yoshinobu 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (70151959)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KUMAGAI Jiro 東京医科歯科大学, 大学院・保険衛生学研究科, 准教授 (80280973)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 前立腺癌 / 前立腺肥大 / Propionibacterium acnes / 細胞内感染 / NF-kB / STAT3 / AID / 発癌 |
|---|
| Research Abstract |
Although we did not find a significant expression of activation-induced cytidine deaminase by the prostatic epithelial cells infected by Propionibacterium acnes that is known to be a cause of chronic prostatitis, we found that P. acnes-infected prostatic gland shows local epithelial expression of transcription factors(NF-kB, and STAT3) which can activate oncogenes in such P. acnes-infected prostatic epithelial cells. These results may explain an aspect of inflammation-associated carcinogenesis of the prostate caused by P. acnes-associated chronic prostatitis.
|
-
-
-
[Journal Article] Association analysis of the NOD2 gene with susceptibility to graft-versus-host disease in a Japanese population2011
Author(s)
Tanabe T, Yamaguchi N, Matsuda K, Yamazaki K, Takahashi S, Tojo A, Onizuka M, Eishi Y, Akiyama H, Ishikawa J, Mori T, Hara M, Koike K, Kawa K, Kawase T, Morishima Y, Amano H, Kobayashi-Miura M, Kakamu T, Nakamura Y, Asano S, Fujita Y
-
Journal Title
Int J Hematol
Volume: 93(6)
Pages: 771-8
Peer Reviewed
-
[Journal Article] Tumor-associated macrophages as major source of APRIL in gastric MALT lymphoma2011
Author(s)
Munari F, Lonardi S, Cassatella MA, Doglioni C, Cangi MG, Amedei A, Facchetti F, Eishi Y, Rugge M, Fassan M, de Bernard M, D' Elios MM, Vermi W
-
Journal Title
Blood
Volume: 16 ; 117(24)
Pages: 6612-6
Peer Reviewed
-
-
[Journal Article] Localization of the invadopodia-related proteins actinin-1 and cortactin to matrix-contact-side cytoplasm of cancer cells in surgically resected lung adenocarcinomas2011
Author(s)
Hirooka S, Akashi T, Ando N, Suzuki Y, Ishida N, Kurata M, Takizawa T, Kayamori K, Sakamoto K, Fujiwara N, Kojima M, Eishi Y
-
Journal Title
Pathobiology
Volume: 78(1)
Pages: 10-23
Peer Reviewed
-
[Journal Article] AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma2011
Author(s)
Namiki T, Tanemura A, Valencia JC, Coelho SG, Passeron T, Kawaguchi M, Vieira WD, Ishikawa M, Nishijima W, Izumo T, Kaneko Y, Katayama I, Yamaguchi Y, Yin L, Polley EC, Liu H, Kawakami Y, Eishi Y, Takahashi E, Yokozeki H, Hearing VJ
-
Journal Title
Proc Natl Acad Sci USA
Volume: 19 ; 108(16)
Pages: 6597-602
Peer Reviewed
-
-
[Journal Article] Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf42011
Author(s)
Iwasaki M, Tsuchiya K, Okamoto R, Zheng X, Kano Y, Okamoto E, Okada E, Araki A, Suzuki S, Sakamoto N, Kitagaki K, Akashi T, Eishi Y, Nakamura T, Watanabe M
-
Journal Title
J Gastroenterol
Volume: 46(2)
Pages: 191-202
Peer Reviewed
-
-
[Journal Article] Propionibacteriumacnes抗体(PAB抗体)免疫染色にて陽性を呈した壊死性サルコイド肉芽腫症の一手術例2011
Author(s)
日比美智子, 中尾彰宏, 住田敦, 小川知美, 岩田知子, 今藤綾乃, 近藤規之, 森岡正貴, 井田〓彦, 森正一, 横山俊彦, 祖開暁彦, 江石義信
-
Journal Title
日本サルコイドーシス/肉芽腫性疾患学会雑誌
Volume: 31(1)
Pages: 33-40
Peer Reviewed
-
-
[Journal Article] カプセル内視鏡では診断できず、ダブルバルーン小腸内視鏡で診断しえた空腸GISTの1例2011
Author(s)
福田将義, 鈴木伸治, 東正新, 長沼誠, 長堀正和, 土屋輝一郎, 坂本直哉, 渡辺守, 岡田英理子, 荒木昭博, 大岡真也, 小林宏敏, 杉原健一, 伊藤栄作, 江石義信
-
Journal Title
Progress of Digestive Endoscopy
Volume: 78(2)
Pages: 124-5
Peer Reviewed
-
[Journal Article] 【EOBにかかわる諸問題】Gd-EOB MRI肝細胞相で内部に異なる信号強度の結節を認めた肝細胞癌の1例2011
Author(s)
小川康介, 野口典男, 三浦智也, 小倉俊郎, 光法雄介, 松村聡, 伴大輔, 入江工, 工藤篤, 中村典明, 田中真二, 有井滋樹, 市村香代子, 江石義信
-
Journal Title
Liver Cancer
Volume: 17(1)
Pages: 15-22
Peer Reviewed
-
-
[Presentation] 術前化学療法および再発後化学療法が奏功した膵癌の1切除例
Author(s)
三浦智也,伴大輔,工藤篤,小倉俊郎,光法雄介,松村聡,入江工,野口典男,中村典明,田中真二,猪狩亨,江石義信,有井滋樹
Organizer
第23回日本肝胆膵外科学会・学術集会
-
-
-
-
-
-
-
-
-
-
[Presentation] Y-glutamylcyclotransferaseの食道扁平上皮癌における発現増強の意義
Author(s)
北垣慶介,河内洋,関根正喜,天野与稔,内田佳介,古川あすか,鈴木好美,山田哲夫,河野辰幸, BoardPhilip,江石義信
Organizer
第100回日本病理学会総会
-
-
-
-
-
-
-
-
-
-
-
