2012 Fiscal Year Final Research Report
Mechanisms of abnormal organogenesis and histogenesis of the kidney and ureter and development of the embryonic treatment
| Project/Area Number |
22659289
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Shimane University |
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Principal Investigator |
OTANI Hiroki 島根大学, 医学部, 教授 (20160533)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Akihiro 島根大学, 医学部, 助教 (70346378)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 奇形学 |
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| Research Abstract |
We have clarified that cell rearrangements including convergent extension are involved in elongation of the ureter and ‘elevation’ of the kidney, and observed interkinetic nuclear migration-like nuclear movement in the proliferating epithelial cells of the ureter. The exo-utero manipulation/development system, a method to modify the organogenesis and histogenesis of organs including the ureter, has been improved by echo-guidance and other refinements for the more accurately targeted injection. Although we could not obtain conclusive results in the ureter-related experiments, we could successfully modify the histogenesis in the experiments of the musculoskeletal system.
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