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2012 Fiscal Year Final Research Report

Mechanisms of abnormal organogenesis and histogenesis of the kidney and ureter and development of the embryonic treatment

Research Project

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Project/Area Number 22659289
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionShimane University

Principal Investigator

OTANI Hiroki  島根大学, 医学部, 教授 (20160533)

Co-Investigator(Kenkyū-buntansha) MATSUMOTO Akihiro  島根大学, 医学部, 助教 (70346378)
Project Period (FY) 2010 – 2012
Keywords奇形学
Research Abstract

We have clarified that cell rearrangements including convergent extension are involved in elongation of the ureter and ‘elevation’ of the kidney, and observed interkinetic nuclear migration-like nuclear movement in the proliferating epithelial cells of the ureter. The exo-utero manipulation/development system, a method to modify the organogenesis and histogenesis of organs including the ureter, has been improved by echo-guidance and other refinements for the more accurately targeted injection. Although we could not obtain conclusive results in the ureter-related experiments, we could successfully modify the histogenesis in the experiments of the musculoskeletal system.

  • Research Products

    (18 results)

All 2013 2012 2011 2010

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (9 results)

  • [Journal Article] fect of leptin dministration on myelination in ob/ob mouse cerebrum after birth2013

    • Author(s)
      Hashimoto R, Matsumoto A, Udagawa J, Hioki K, Otani H
    • Journal Title

      Neuroreport

      Volume: 24 Pages: 22-29

    • DOI

      DOI:10.1097/WNR.0b013e32835ba875

    • Peer Reviewed
  • [Journal Article] Interkinetic nuclear migration during early development of midgut and ureteric epithelia2013

    • Author(s)
      Yamada M, Udagawa J, Hashimoto R, Matsumoto A, Hatta T, Otani H
    • Journal Title

      Anat. Sci. Int

      Volume: 88 Pages: 31-37

    • Peer Reviewed
  • [Journal Article] Mathematical analysis of mandibular morphogenesis by micro-CT-based mouse and alizarin red S-stained-based human studies during development2012

    • Author(s)
      Rafiq AM, Udagawa J, Lundth T, Jahan E, Matsumoto A, Sekine J, Otani H
    • Journal Title

      Anat Rec

      Volume: 295 Pages: 313-327

    • DOI

      DOI:10.1002/ar.21535

    • Peer Reviewed
  • [Journal Article] Stage-specific changes in the levels of granulocyte-macrophagecolony-stimulating factor and its receptor in the biological fluid and organ of mouse fetuses2011

    • Author(s)
      Matsumoto A, Hatta T, Ono A, Hashimoto R, Otani H
    • Journal Title

      Congenit Anom

      Volume: 51 Pages: 183-186

    • DOI

      DOI:10.1111/j.1741-4520.2011.00337.x.

    • Peer Reviewed
  • [Journal Article] Adrenocorticotropic tumor cells transplanted into mouse embryos affect pancreatic histogenesis2011

    • Author(s)
      Kawamoto M, Udagawa J, Hashimoto R, Matsumoto A, Yamada M, Nimura M, Otani H
    • Journal Title

      Congenit Anom

      Volume: 51 Pages: 62-69

    • DOI

      DOI:10.1111/j.1741-4520.2010.00313.x.

    • Peer Reviewed
  • [Journal Article] Effects of melanocortins on fetal development2011

    • Author(s)
      Simamura E, Shimada H, Shoji H, Otani H, Hatta T
    • Journal Title

      Congenit Anom

      Volume: 51 Pages: 47-54

    • DOI

      DOI:10.1111/j.1741-4520.2011.00316.x.

    • Peer Reviewed
  • [Journal Article] Direct and indirect effects of neuropeptide Y and neurotrophin 3 on myelination in the neonatal brains2011

    • Author(s)
      Hashimoto R, Udagawa J, Kagohashi Y, Matsumoto A, Hatta T, Otani H
    • Journal Title

      Brain Res

      Volume: 1373 Pages: 55-66

    • DOI

      DOI:10.1016/j.brainres.2010.12.027

    • Peer Reviewed
  • [Journal Article] Individual variation in organ histogenesis as a causative factor in the developmental origins of health and disease2010

    • Author(s)
      Otani H, Udagawa J, Hatta T, Kagohashi Y, Hashimoto R, Matsumoto A, Satow F, Nimura M
    • Journal Title

      Unnoticed congenital anomalies? Congenit Anom

      Volume: 50 Pages: 205-211

    • Peer Reviewed
  • [Journal Article] Effects of restriction of fetal jaw movement on prenatal development of thetemporalis muscle2010

    • Author(s)
      Jahan E, Matsumoto A, Udagawa J, Rafiq AM, Hashimoto R, Rahman OI, Habib H, Sekine J, Otani H
    • Journal Title

      Effects of restriction of fetal jaw movement on prenatal development of thetemporalis muscle

      Volume: 55 Pages: 919-927

    • DOI

      DOI:10.1016/j.archoralbio.2010.07.010.

    • Peer Reviewed
  • [Presentation] マウス胎仔の脳組織形成における顆粒球・マクロファージコロニー刺激因子の作用の解析2013

    • Author(s)
      松本暁洋、Rafiq Ashiq M、八田稔久、橋本龍樹、大谷 浩
    • Organizer
      第118回日本解剖学会全国学術集会
    • Place of Presentation
      サンポートホール高松(高松市)
    • Year and Date
      20130328-30
  • [Presentation] 子宮外発生法を用いた軟骨内骨化における軟骨細胞増殖,分化・肥大,細胞死調節因子の in vivo 解析2013

    • Author(s)
      井上隆之、橋本龍樹、松本暁洋、Esrat Jahan、宇田川 潤、 八田稔久、 大谷 浩
    • Organizer
      第118回日本解剖学会全国学術集会
    • Place of Presentation
      サンポートホール高松(高松市)
    • Year and Date
      20130328-30
  • [Presentation] Prenatal jaw movement affects molecular cascade in the mandibular condylar cartilage development2012

    • Author(s)
      Jahan E, Hashimoto R, Matsumoto A, Rafiq AM, Udagawa J, Sekine J, Otani H
    • Organizer
      Joint Meeting of the 45th Annual Meeting of the Japanese Society of Developmental Biologists & the 64th Annual Meeting of the Japan Society for Cell Biology
    • Place of Presentation
      Kobe International Conference Center (Kobe, Japan)
    • Year and Date
      20120528-31
  • [Presentation] 子宮外発生法を用いた筋腱結合部形成過程における細胞‐細胞外マトリクス相互作用の実験的解析.2012

    • Author(s)
      Kobe International Conference Center (Kobe, Japan)
    • Organizer
      第117回日本解剖学会全国学術集会
    • Place of Presentation
      第117回日本解剖学会全国学術集会
    • Year and Date
      20120326-28
  • [Presentation] Fetal jaw movement affects molecular cascade in the development of mandibular condylar cartilage2012

    • Author(s)
      Jahan E, Udagawa J, Matsumoto A, Rafiq AM, Sekine J, Otani H
    • Organizer
      Fetal jaw movement affects molecular cascade in the development of mandibular condylar cartilage
    • Place of Presentation
      Fetal jaw movement affects molecular cascade in the development of mandibular condylar cartilage
    • Year and Date
      20120326-28
  • [Presentation] 知られざる先天異常 臓器の組織形成における個体差と疾病素因の関り-.2011

    • Author(s)
      大谷 浩
    • Organizer
      知られざる先天異常 臓器の組織形成における個体差と疾病素因の関り-.
    • Place of Presentation
      知られざる先天異常 臓器の組織形成における個体差と疾病素因の関り-.
    • Year and Date
      2011-08-11
  • [Presentation] Epithelial cell rearrangement contributes the ureteral elongation in human and mouse embryos2010

    • Author(s)
      山田真紀子、和気功治、宇田川潤、八田稔久、橋本龍樹、松本暁洋、椎名浩昭、井川幹夫、大谷 浩
    • Organizer
      第50回日本先天異常学会
    • Place of Presentation
      第50回日本先天異常学会
    • Year and Date
      20100708-10
  • [Presentation] Fetal jaw movement affects Indian hedgehog signaling in mandibular condylar cartilage development2010

    • Author(s)
      Jahan E, Udagawa J, Matsumoto A, Rafiq AM, Sekine J, Otani H
    • Organizer
      第50回日本先天異常学会
    • Place of Presentation
      淡路夢舞台国際会議場(淡路市)
    • Year and Date
      20100708-10
  • [Presentation] 臓器の組織形成と疾病の素因形成のかかわり2010

    • Author(s)
      大谷 浩
    • Organizer
      (特別講演)第21回日本成長学会学術集会
    • Place of Presentation
      (特別講演)第21回日本成長学会学術集会
    • Year and Date
      2010-11-13

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Published: 2014-08-29   Modified: 2015-10-15  

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