Brain activation measurement by NIRS in response to bladder behavior

2012 Fiscal Year Final Research Report

• Project/Area Number: 22659291
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Toho University
• Principal Investigator: SAKAKIBARA Ryuji 東邦大学, 医学部, 准教授 (00282476)
• Project Period (FY): 2010 – 2012
• Keywords: 排尿学

Research Abstract

Aim of this study is to explore brain activity in the frontal micturition area during natural bladder behaviour. Five control subjects (one man and four women; mean age 61 years [38-70]) and four subjects with detrusor overactivity(all men; mean age 55 years [33-65]) were enrolled in the study. We performed real-time measurements of oxyhemoglobin concentration (oxy-Hb) changes in the frontal micturition area using functional near-infrared spectroscopy (fNIRS) in response to quasi-natural, continuous bladder filling and voiding in a sitting position. In the control group the following results were obtained: 1) a slight increase ofoxy-Hb before first sensation occurred, 2) there was a continuous increase of oxy-Hb during bladder filling to the point just after voiding began, 3) there was a continuous decrease of oxy-Hb after voiding, 4) in subjects who were unable to urinate, oxy-Hb also decreased after attempting to void, and 5) the area activated was the bilateral lateral prefrontal area, particularly Brodmann’s areas 8, 10 and 46. In the detrusor overactivity group, 6) an increase of oxy-Hb before first sensation was rare and frontal cortical activation was weak, 7) at the moment detrusor overactivity appeared, fNIRS brain activity in the frontal cortex did not change significantly; and otherwise the results were almost the same as those inthe control group. This study shows that the frontal micturition area is activated during natural bladder filling and voiding using fNIRS. We were also able to show normalization of decreased prefrontal activity after administration of anticholinergics.

Research Products

• [Journal Article] パーキンソン病患者の上部消化管運動機能評価における13C呼気検査の応用 (2011)
  • Author(s): 土井啓員, 榊原隆次, 平井成和, 真坂亙, 岸雅彦, 小川恵美奈, 舘野冬樹, 石井敏浩, 小暮麻由美, 佐藤光利
  • Journal Title: 定同位体と生体ガス Volume: 3(1) Pages: 13-17
  • Peer Reviewed
• [Journal Article] Incidence of emergency intestinal pseudo-obstruction in Parkinson's disease (2011)
  • Author(s): Tateno F, Sakakibara R, Kishi M, Ogawa E, Yoshimatsu Y, Takada N, Suzuki Y, Mouri T, Uchiyama T, Yamamoto T.
  • Journal Title: J Am Geriatr Soc Volume: 59(12) Pages: 2373-5.
  • Peer Reviewed
• [Journal Article] Incidence of emergency intestinal pseudo-obstruction in Parkinson's disease. (2011)
  • Author(s): Tateno F,Sakakibara R, Kishi M, Ogawa E, Yoshimatsu Y, Takada N, Suzuki Y, Mouri T, Uchiyama T, Yamamoto T.
  • Journal Title: J Am Geriatr Soc Volume: 59(12) Pages: 2373-5.
  • Peer Reviewed
• [Journal Article] the members of SINPHONI (Study of Idiopathic Normal Pressure Hydrocephalus On Neurological Improvement) (2011)
  • Author(s): akakibara R, Uchida Y, Ishii K, Kazui H, Hashimoto M, Ishikawa M, Yuasa T, Kishi M, Ogawa E, Tateno F, Uchiyama T, Yamamoto T, Yamanishi T, Terada H;
  • Journal Title: Correlation of right frontal hypoperfusion and urinary dysfunction in iNPH: A SPECT study.Neurourol Urodyn
  • DOI: doi: 10.1002/nau.21222.
  • Peer Reviewed
• [Journal Article] Alpha-synuclein in the Cerebrospinal Fluid Differentiates Synucleinopathies (Parkinson Disease, Dementia With Lewy Bodies, Multiple System Atrophy) From Alzheimer Disease. (2011)
  • Author(s): Tateno F, Sakakibara R, Kawai T, Kishi M, Murano T
  • Journal Title: Alzheimer Dis Assoc Disord.
  • Peer Reviewed
• [Journal Article] Pathophysiology of bladder dysfunction in Parkinson's disease (2011)
  • Author(s): Sakakibara R, Tateno F, Kishi M, Tsuyuzaki Y, Uchiyama T, Yamamoto T.
  • Journal Title: Neurobiol Dis
  • Peer Reviewed
• [Journal Article] Bladder, bowel, and sexual dysfunction in Parkinson's disease. (2011)
  • Author(s): Sakakibara R, Kishi M, Ogawa E, Tateno F, Uchiyama T, Yamamoto T, Yamanishi T.
  • Journal Title: Parkinsons Dis Pages: 924605.
  • Peer Reviewed
• [Journal Article] Stroke and Cardio-ankle Vascular Stiffness Index (2011)
  • Author(s): Suzuki J, Sakakibara R, Tomaru T, Tateno F, Kishi M, Ogawa E, Kurosu T, Shirai K.
  • Journal Title: J Stroke Cerebrovasc Dis.
  • Peer Reviewed
• [Journal Article] Acute, severe constipation in a 58-year-old Japanese patient. (2011)
  • Author(s): Hosoe N, Sakakibara R, Yoshida M, Wakabayashi T, Kikuchi H, Yamada T, Kawahara K, Kishi M.
  • Journal Title: Gut Volume: 60(8) Pages: 1059, 1093.
  • Peer Reviewed
• [Journal Article] A Multicenter Brain Perfusion SPECT Study Evaluating Idiopathic Normal-Pressure Hydrocephalus on Neurological Improvement. (2011)
  • Author(s): Ishii K, Hashimoto M, Hayashida K, Hashikawa K, Chang CC, Nakagawara J, Nakayama T, Mori S, Sakakibara R.
  • Journal Title: Dement Geriatr Cogn Disord. Volume: 32(1) Pages: 1-10.
  • Peer Reviewed
• [Journal Article] Kishi M, Sakakibara R, Ogawa E, Tateno F, Takahashi O, Koga M. (2011)
  • Author(s): Kishi M, Sakakibara R, Ogawa E, Tateno F, Takahashi O, Koga M.
  • Journal Title: Neurol Sci
  • Peer Reviewed
• [Journal Article] Hashimoto's Ophthalmopathy. (2011)
  • Author(s): Tateno F, Sakakibara R, Kishi M, Ogawa E
  • Journal Title: Am J Med Sci. Volume: 342(1) Pages: 342(1)
  • Peer Reviewed
• [Journal Article] Levodopa ameliorated anorectal constipation in de novo Parkinson's disease: The QL-GAT study. (2011)
  • Author(s): Tateno F, Sakakibara R, Yokoi Y, Kishi M, Ogawa E, Uchiyama T, Yamamoto T, Yamanishi T, Takahashi O.
  • Journal Title: Parkinsonism Relat Disord
  • Peer Reviewed
• [Journal Article] Constipation triggered the malignant syndrome in Parkinson's disease. (2011)
  • Author(s): Ogawa E, Sakakibara R, Kishi M, Tateno F.
  • Journal Title: Neurol Sci
  • Peer Reviewed
• [Journal Article] Sensitivity andspecificity of metaiodobenzylguanidine (MIBG) myocardial accumulation in the diagnosis of Lewy body diseases in a movement disorder clinic (2011)
  • Author(s): Tateno F, Sakakibara R, Kishi M, Ogawa E, Terada H, Ogata T, Haruta H.
  • Journal Title: Parkinsonism Relat Disord. Volume: 17(5) Pages: 395-7.
  • Peer Reviewed
• [Journal Article] Pure akinesia with low myocardial metaiodobenzylguanidine uptake (2011)
  • Author(s): Tateno F, Sakakibara R, Kishi M, Ogawa E
  • Journal Title: Parkinsonism Relat Disord Volume: 17(5) Pages: 357-9.
  • Peer Reviewed
• [Journal Article] VGCC antibody-positive paraneoplastic cerebellar degeneration presenting with positioning vertigo. (2011)
  • Author(s): Ogawa E, Sakakibara R, Kawashima K, Yoshida T, Kishi M, Tateno F, Kataoka M, Kawashima T, Yamamoto M.
  • Journal Title: Neurol Sci
  • Peer Reviewed
• [Journal Article] Urinary dysfunction in early and untreated Parkinson's disease (2011)
  • Author(s): Uchiyama T, Sakakibara R, Yamamoto T, Ito T, Yamaguchi C, Awa Y, Yanagisawa M, Higuchi Y, Sato Y, Ichikawa T, Yamanishi T, Hattori T, Kuwabara S
  • Journal Title: J Neurol Neurosurg Psychiatry.
  • Peer Reviewed
• [Journal Article] Lateral medullary infarction presenting as isolated vertigo and unilateral loss of visual suppression. (2011)
  • Author(s): Kishi M, Sakakibara R, Nomura T, Yoshida T, Yamamoto M, Kataoka M, Ogawa E, Tateno F.
  • Journal Title: Neurol Sci.
  • Peer Reviewed
• [Journal Article] Pathogenesis of reduced or increased bladder sensation. (2011)
  • Author(s): Tsunoyama K, Sakakibara R, Yamaguchi C, Uchiyama T, Yamamoto T, Yamanishi T, Takahashi O, Sugiyama M, Kishi M, Ogawa E.
  • Journal Title: Neurourol Urodyn. Volume: 30(3) Pages: 339-43.
  • Peer Reviewed
• [Journal Article] Does levodopa affect metaiodobenzylguanidine myocardial accumulation in Parkinson's disease? (2011)
  • Author(s): Kishi M, Sakakibara R, Terada H, Ogawa E, Tateno T
  • Journal Title: Mov Disord. Volume: 26(3) Pages: 564-5.
  • Peer Reviewed
• [Journal Article] Progressive supranuclear palsy presenting with urinary retention and sleep apnea (2011)
  • Author(s): Tateno F, Sakakibara R, Kishi M, Yuasa T, Ogawa E, Takahashi O, Yoshio S, Sugiyama M, Uchiyama T, Yamamoto T, Yamanishi T
  • Journal Title: ClinAuton Res
  • Peer Reviewed
• [Journal Article] Pelvic organ dysfunction is more prevalent and severe in MSA-P compared to parkinson's disease (2011)
  • Author(s): Yamamoto T, Sakakibara R, Uchiyama T, Yamaguchi C, Nomura F, Ito T, Yanagisawa M, Yano M, Awa Y, Yamanishi T, Hattori T, Kuwabara S.
  • Journal Title: Neurourol Urodyn Volume: 30(1) Pages: 102-7.
  • Peer Reviewed
• [Journal Article] Zoster lower cranial neuropathy: a case report and a review of literature (2011)
  • Author(s): Tateno F, Sakakibara R, Kishi M, Ogawa E, Tsuyusaki Y, Yoshida T, Yamamoto M
  • Journal Title: Am J Case Reports. Volume: 12 Pages: 137-139.
  • Peer Reviewed
• [Journal Article] Crohn's disease and stroke in a young adult. (2011)
  • Author(s): Ogawa E, Sakakibara R, Yoshimatsu Y, Suzuki Y, Mouri T, Tateno F, Kishi M, Oda S, Imamura H.
  • Journal Title: Intern Med Volume: 50(20) Pages: 2407-8.
  • Peer Reviewed
• [Journal Article] Ogawa E, Sakakibara R, Kishi M, Tateno F. (2011)
  • Author(s): Ogawa E, Sakakibara R, Kishi M, Tateno F.
  • Journal Title: Intern Med Volume: 50(16) Pages: 1785.
  • Peer Reviewed
• [Journal Article] Meningitis-retention Syndrome: First Case of Urodynamic Follow-up. (2011)
  • Author(s): Tateno F, Sakakibara R, Sugiyama M, Takahashi O, Kishi M, Ogawa E, Uchiyama T, Yamamoto T, Yamanishi T, Yano H, Suzuki H.
  • Journal Title: Intern Med Volume: 50(12) Pages: 1329-32.
  • Peer Reviewed
• [Journal Article] A case of brainstem hypertensive encephalopathy. (2011)
  • Author(s): Ogawa E, Sakakibara R, Tateno F, Kishi M, Nakagami T, Terada H.
  • Journal Title: Am J Case Reports Volume: 12 Pages: 95-97.
  • Peer Reviewed
• [Journal Article] Efficacy of extended-release tolterodine for the treatment of neurogenic detrusor overactivity and/or low-compliance bladder (2010)
  • Author(s): Watanabe M, Yamanishi T, Honda M, Sakakibara R, Uchiyama T, Yoshida K.
  • Journal Title: Int JUrol. Volume: 17(11) Pages: 931-6.
  • Peer Reviewed
• [Journal Article] Sensorimotor manifestations without autonomic symptoms in two siblings with TTR Val107 familial amyloid polyneuropathy. (2010)
  • Author(s): Asahina M, Akaogi Y, Misawa S, Kanai K, Ando Y, Sakakibara R, Arai K, Hattori T, Kuwabara S.
  • Journal Title: Clin Neurol Neurosurg
  • Peer Reviewed
• [Journal Article] Dehydration encephalopathy: a neurological emergency in the older adults. (2010)
  • Author(s): Sakakibara R, Kishi M, Ogawa E, Tateno F, Ogata T, Haruta H, Matsuzawa Y, Shirai K.
  • Journal Title: Am Geriatr Soc. Volume: 58(9) Pages: 1819-21.
  • Peer Reviewed
• [Journal Article] Dentatorubral pallidoluysian atrophy presenting with urinary retention. (2010)
  • Author(s): Sakakibara R, Kishi M, Ogawa E, Yuasa J, Isaka S, Uchiyama T, Yamanishi T.
  • Journal Title: Mov Disord. Volume: 25(12) Pages: 1996-7.
  • Peer Reviewed
• [Journal Article] Multiple-system atrophy presenting with low rectal compliance and bowel pain. (2010)
  • Author(s): Sakakibara R, Kishi M, Ogawa E, Takahashi O, Sugiyama M, Uchiyama T, Yamamoto T, Yaman is h i T.
  • Journal Title: Mov Disord. Volume: 25(10) Pages: 1516-8.
  • Peer Reviewed
• [Journal Article] Editorial comment to effect ofdominant hemispheric stroke on detrusor function in patients with lower urinary tract symptoms. (2010)
  • Author(s): 25(10)
  • Journal Title: Int J Urol. Volume: 17(7) Pages: 660.
  • Peer Reviewed
• [Journal Article] Real-time measurement of oxyhemoglobin concentration changes in the frontal micturition area: an fNIRS study (2010)
  • Author(s): Sakakibara R, Tsunoyama K, Takahashi O, Sugiyama M, Kishi M, Ogawa E, Uchiyama T, Yamamoto T, Yamanishi T, Awa Y, Yamaguchi C.
  • Journal Title: Neurourol Urodyn. Volume: 29(5) Pages: 757-64.
  • Peer Reviewed
• [Journal Article] Clinical guidelines for nocturia. (2010)
  • Author(s): Committee for Establishment of the Clinical Guidelines for Nocturia of the Neurogenic Bladder Society.
  • Journal Title: Int J Urol. Volume: 17(5) Pages: 397-409.
  • Peer Reviewed
• [Journal Article] Bupivacaine-induced chemical meningitis (2010)
  • Author(s): Tateno F, Sakakibara R, Kishi M, Ogawa E.
  • Journal Title: J Neurol Volume: 257(8) Pages: 1327-9.
  • Peer Reviewed
• [Journal Article] Good maternal and fetal outcomes of predominantly sensory Guillain-Barre syndrome in pregnancy after intravenous immunoglobulin. (2010)
  • Author(s): Matsuzawa Y, Sakakibara R, Shoda T, Kishi M, Ogawa E.
  • Journal Title: Neurol Sci Volume: 31(2) Pages: 201-3.
  • Peer Reviewed
• [Journal Article] Neuronal activities of forebrain structures with respect to bladder contraction in cats. (2010)
  • Author(s): Yamamoto T, Sakakibara R, Nakazawa K, Uchiyama T, Shimizu E, Hattori T, Kuwabara S.
  • Journal Title: Neurosci Lett Volume: 473(1) Pages: 42-7.
  • Peer Reviewed
• [Journal Article] Genitourinary dysfunction in Parkinson's disease. (2010)
  • Author(s): Sakakibara R, Uchiyama T, Yamanishi T, Kishi M.
  • Journal Title: Mov Disord Volume: 25(1 Pages: 2-12
  • Peer Reviewed
• [Journal Article] Influence of Body Position on Defecation in Humans. (2010)
  • Author(s): Sakakibara R, Tsunoyama K, Hosoi H, Takahashi O, Sugiyama M, Kishi M, Ogawa E, Terada H, Uchiyama T, Yamanishi T
  • Journal Title: LUTS Volume: 2 Pages: 16-21
  • Peer Reviewed
• [Journal Article] ICI 2009 Committee 10. Neurologic fecal incontinence. (2010)
  • Author(s): Wyndaele JJ, Kovindha A, Igawa Y, Madersbacher H, Radziszewski P, Ruffion A, Schurch B, Castro D, Sakakibara R, Wein A
  • Journal Title: Neurourol Urodyn. Volume: 29(1) Pages: 207-12.
  • Peer Reviewed
• [Journal Article] Wein A. Committe 10 on Neurogenic Bladder and Bowel of the International Consultation on Incontinence 2008-2009. Neurologic urinary incontinence. (2010)
  • Author(s): Wyndaele JJ, Kovindha A, Madersbacher H, Radziszewski P, Ruffion A, Schurch B, Castro D, Igawa Y, Sakakibara R
  • Journal Title: Neurourol Urodyn. Volume: 29(1) Pages: 159-64.
  • Peer Reviewed
• [Journal Article] Herbal medicine-induced meningitis-retention syndrome. (2010)
  • Author(s): Takahashi O, Sakakibara R, Kishi M, Matsuzawa Y, Ogawa E, Sugiyama M, Uchiyama T, Yamamoto T, Yamanishi T, Tomaru T.
  • Journal Title: Intern Med. Volume: 49(16) Pages: 1813-6.
  • Peer Reviewed
• [Book] Cambridge University Press. Pelvic Organ Dysfunction in Neurological Disease (2010)
  • Author(s): Sakakibara R, Fowler CJ, Hattori T.
  • Total Pages: 349.
  • Publisher: Clinical Management & Rehabilitation.
• [Remarks]
  • URL: http://www.lab.toho-u.ac.jp/med/sakura/neurology/