2012 Fiscal Year Final Research Report
Brain activation measurement by NIRS in response to bladder behavior
| Project/Area Number |
22659291
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 排尿学 |
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| Research Abstract |
Aim of this study is to explore brain activity in the frontal micturition area during natural bladder behaviour. Five control subjects (one man and four women; mean age 61 years [38-70]) and four subjects with detrusor overactivity(all men; mean age 55 years [33-65]) were enrolled in the study. We performed real-time measurements of oxyhemoglobin concentration (oxy-Hb) changes in the frontal micturition area using functional near-infrared spectroscopy (fNIRS) in response to quasi-natural, continuous bladder filling and voiding in a sitting position. In the control group the following results were obtained: 1) a slight increase ofoxy-Hb before first sensation occurred, 2) there was a continuous increase of oxy-Hb during bladder filling to the point just after voiding began, 3) there was a continuous decrease of oxy-Hb after voiding, 4) in subjects who were unable to urinate, oxy-Hb also decreased after attempting to void, and 5) the area activated was the bilateral lateral prefrontal area, particularly Brodmann’s areas 8, 10 and 46. In the detrusor overactivity group, 6) an increase of oxy-Hb before first sensation was rare and frontal cortical activation was weak, 7) at the moment detrusor overactivity appeared, fNIRS brain activity in the frontal cortex did not change significantly; and otherwise the results were almost the same as those inthe control group. This study shows that the frontal micturition area is activated during natural bladder filling and voiding using fNIRS. We were also able to show normalization of decreased prefrontal activity after administration of anticholinergics.
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Research Products
(46 results)
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[Journal Article] the members of SINPHONI (Study of Idiopathic Normal Pressure Hydrocephalus On Neurological Improvement)2011
Author(s)
akakibara R, Uchida Y, Ishii K, Kazui H, Hashimoto M, Ishikawa M, Yuasa T, Kishi M, Ogawa E, Tateno F, Uchiyama T, Yamamoto T, Yamanishi T, Terada H;
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Journal Title
Correlation of right frontal hypoperfusion and urinary dysfunction in iNPH: A SPECT study.Neurourol Urodyn
DOI
Peer Reviewed
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[Journal Article] Kishi M, Sakakibara R, Ogawa E, Tateno F, Takahashi O, Koga M.2011
Author(s)
Kishi M, Sakakibara R, Ogawa E, Tateno F, Takahashi O, Koga M.
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Journal Title
Peer Reviewed
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[Journal Article] Urinary dysfunction in early and untreated Parkinson's disease2011
Author(s)
Uchiyama T, Sakakibara R, Yamamoto T, Ito T, Yamaguchi C, Awa Y, Yanagisawa M, Higuchi Y, Sato Y, Ichikawa T, Yamanishi T, Hattori T, Kuwabara S
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Journal Title
J Neurol Neurosurg Psychiatry.
Peer Reviewed
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[Journal Article] Progressive supranuclear palsy presenting with urinary retention and sleep apnea2011
Author(s)
Tateno F, Sakakibara R, Kishi M, Yuasa T, Ogawa E, Takahashi O, Yoshio S, Sugiyama M, Uchiyama T, Yamamoto T, Yamanishi T
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Journal Title
Peer Reviewed
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[Journal Article] Pelvic organ dysfunction is more prevalent and severe in MSA-P compared to parkinson's disease2011
Author(s)
Yamamoto T, Sakakibara R, Uchiyama T, Yamaguchi C, Nomura F, Ito T, Yanagisawa M, Yano M, Awa Y, Yamanishi T, Hattori T, Kuwabara S.
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Journal Title
Neurourol Urodyn
Volume: 30(1)
Pages: 102-7.
Peer Reviewed
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[Journal Article] Meningitis-retention Syndrome: First Case of Urodynamic Follow-up.2011
Author(s)
Tateno F, Sakakibara R, Sugiyama M, Takahashi O, Kishi M, Ogawa E, Uchiyama T, Yamamoto T, Yamanishi T, Yano H, Suzuki H.
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Journal Title
Intern Med
Volume: 50(12)
Pages: 1329-32.
Peer Reviewed
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[Journal Article] Real-time measurement of oxyhemoglobin concentration changes in the frontal micturition area: an fNIRS study2010
Author(s)
Sakakibara R, Tsunoyama K, Takahashi O, Sugiyama M, Kishi M, Ogawa E, Uchiyama T, Yamamoto T, Yamanishi T, Awa Y, Yamaguchi C.
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Journal Title
Neurourol Urodyn.
Volume: 29(5)
Pages: 757-64.
Peer Reviewed
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