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2012 Fiscal Year Final Research Report

The role of LH/hCG in uterine endometrium for fertility

Research Project

  • PDF
Project/Area Number 22659295
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionGunma University

Principal Investigator

MINEGISHI Takashi  群馬大学, 大学院・医学系研究科, 教授 (00209842)

Project Period (FY) 2010 – 2012
KeywordsLH/hCG / 子宮 / LH/hCG receptor
Research Abstract

We have detected LH/hCG receptor mRNA in the immature rat uterus by Northern blot and down-regulation of this receptor mRNA in the PMSG-hCG treated immature rats. Mvk, an LHR mRNA-binding protein, has been shown to accelerate LHR mRNA instability in the ovary. In the uterus, Mvk increased after PMSG treatment of immature rats and decreased after hCG treatment. The cultured uterus displayed an hCG concentration-dependent increase in cAMP production in medium. The immunohistochemical experiment showed that these receptor proteins are expressed in the epithelial cells of endometrium. These results suggest that functional LH/hCG receptors are present in the immature rat uterus and are down-regulated and up-regulated by signals resulting from hCG treatment.

  • Research Products

    (12 results)

All 2013 2012 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (7 results)

  • [Journal Article] Glucose-Regulated Protein, 78-Kilodalton as a Modulator of Luteinizing Hormone Receptor Expression in Luteinizing Granulosa Cells in Rats.2013

    • Author(s)
      Kogure K, Nakamura K, Ikeda S, Kitahara Y, Nishimura T, Iwamune M, Minegishi T.
    • Journal Title

      Biol Reprod

      Volume: 88(1) Pages: 8,1-11

    • DOI

      DOI:10.1095/biolreprod.112.101873.

    • Peer Reviewed
  • [Journal Article] GRP78 induced by estrogen plays a role in the chemosensitivity of endometrial cancer.2012

    • Author(s)
      Luvsandagva B, Nakamura K, Kitahara Y, Aoki H, Murata T, Ikeda S, Minegishi T.
    • Journal Title

      Gynecol Oncol

      Volume: 126 Pages: 132-139

    • DOI

      DOI:10.1095/biolreprod.112.101873.

    • Peer Reviewed
  • [Journal Article] Downregulation of LH receptor mRNA in the rat uterus2012

    • Author(s)
      Kasahara Y, Kitahara Y, Nakamura K, Minegishi T.
    • Journal Title

      Mol Med Report

      Volume: 5 Pages: 1146-1150

    • DOI

      DOI:10.3892/mmr.2012.795

    • Peer Reviewed
  • [Journal Article] Lymphangioleiomyomatosis suspectedto be a gynecologic disease2012

    • Author(s)
      Yamashita S, Nakamura K, Shinozaki H, Minegishi T.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 37 Pages: 267-269

    • DOI

      DOI:10.1111/j.1447-0756.2010.01368.x

    • Peer Reviewed
  • [Journal Article] Clusterin expression inversely correlates with chemosensitivity and predicts poor survival in patients with locally advanced cervical cancer treated with cisplatin-based neoadjuvant chemotherapy and radical hysterectomy2010

    • Author(s)
      Watari H, Kanuma T, Ohta Y, Hassan MK, Mitamura T, Hosaka M, Minegishi T, Sakuragi N.
    • Journal Title

      Pathol Oncol Res

      Volume: 16 Pages: 345-352

    • DOI

      DOI:10.1007/s12253-009-9235-0

    • Peer Reviewed
  • [Presentation] The Leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility2012

    • Author(s)
      Yamashita S, Minegishi T, Ascoli M.
    • Organizer
      15th International Congress on Hormonal Steroids and Hormones & Cancer
    • Place of Presentation
      石川音楽堂(石川)
    • Year and Date
      2012-11-16
  • [Presentation] ラット子宮におけるLH受容体(LHR)の発現調節2012

    • Author(s)
      笠原慶充、北原慈和、中村和人、峯岸敬
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      神戸国際展示場(神戸)
    • Year and Date
      2012-04-13
  • [Presentation] Pathophysiology of PCOS2011

    • Author(s)
      Minegishi T
    • Organizer
      FertiLink 2011
    • Place of Presentation
      釜山(韓国)
    • Year and Date
      2011-11-06
  • [Presentation] ラット卵巣LH受容体(LHR)の発現調節における、GRP78とmiRNAの関係について2011

    • Author(s)
      岩宗政幸、北原慈和、小暮佳代子、中村和人、峯岸敬
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2011-08-29
  • [Presentation] Role of microRNA in the Expression of Luteinizing Hormone-Human Chorionic Gonadotropin Receptor mRNA in Rat Ovary2011

    • Author(s)
      Kitahara Y, Nakamura K, Kogure K, Minegishi T
    • Organizer
      Endo2011:93th Annual Meeting
    • Place of Presentation
      ボストン(米国)
    • Year and Date
      2011-06-04
  • [Presentation] 帝王切開瘢痕部妊娠14例の臨床的検討2010

    • Author(s)
      岸裕司、伊藤理廣、五十嵐茂雄、今井文晴、峯岸敬
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2010-04-25
  • [Presentation] 子宮体癌に対し、分子シャペロンの発現の意味2010

    • Author(s)
      ルブサンダクワバイガルマー、中村和人、青木宏、平川隆史、村田知美、池田禎智、小暮佳代子、北原慈和、峯岸敬
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2010-04-23

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Published: 2014-08-29  

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