Development of the cure by the transgenics using the nano bubble to the Recklinghausen disease

2011 Fiscal Year Final Research Report

• Project/Area Number: 22659319
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Plastic surgery
• Research Institution: Tohoku University
• Principal Investigator: TACHI Masahiro 東北大学, 大学院・医学系研究科, 教授 (50312004)
• Co-Investigator(Kenkyū-buntansha): KODAMA Tetsuya 東北大学, 大学院・医学系研究科, 教授 (40271986) ; IMAI Yoshimichi 東北大学, 大学院・医学系研究科, 准教授 (80323012)
• Project Period (FY): 2010 – 2011
• Keywords: レッグリングハウゼン病 / NFI遺伝子 / ナノバブル / 遺伝子導入 / 遺伝子治療

Research Abstract

Initially the aim of this study was development of a gene therapy of von Recklinghausen's disease. However, because it became clear that integration of NF-1 gene into the vector was difficult, we have changed the target to Malignant peripheral nerve sheath tumor (MPNST), complicating disease of von Recklinghausen's disease.
We have observed a marked decrease in number of cells by transfection of IFN-α and IFN-γ gene into cells delived from MPNST.