2011 Fiscal Year Final Research Report
The development of small diameter artificial vessels consisted with PVA hydrogel
| Project/Area Number |
22659322
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Plastic surgery
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| Research Institution | Kobe University |
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Principal Investigator |
TAHARA Shinya 神戸大学, 医学部付属病院, 教授 (60207206)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIKAWA Kazunobu 神戸大学, 医学部附属病院, 特命講師 (90403237)
SAKAKIBARA Shunsuke 神戸大学, 医学研究科, 特命助教 (50444592)
TSUTSUMI Sadami 日本大学, 歯学部, 教授 (00028739)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 再生医学 |
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| Research Abstract |
The small diameter(3mm) conduit consisted with PVA hydrogel was transplanted to rat abdominal artery. Immediately after the transplantation, beating was observed, however, all conduits were occulted in a few days. Next, endothelial cells were co-cultured with PVA sheet. No endothelial cells were adhered to PVA sheet. The collagen fragment was embedded into PVA hydrogel and endothelial cells were co-cultured with rotation. These cells were, then, adhered and migrated. In addition, smooth muscle cells were co-cultures, and these cells also adhered to the collagen-PVA sheet.
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