2011 Fiscal Year Final Research Report
Does cytokine directly reacted with bacteria?
| Project/Area Number |
22659333
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松尾 美樹 鹿児島大学, 医歯学総合研究科口腔微生物学分野 (20527048)
大貝 悠一 鹿児島大学, 医歯学総合研究科口腔微生物学分野 (40511259)
神原 賢治 鹿児島大学, 医歯学総合研究科口腔微生物学分野 (60305141)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 細菌 / 歯学 / サイトカイン / 細菌感染 |
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| Research Abstract |
The purpose of this research is to demonstrate the new function of cytokines. We investigated the antibacterial activity of cytokines, the cytokine affinity to bacterial cells and the effect of cytokine treatment on bacterial attachment to mammal cells. We found that MIP3alpha and IL8, positive charged peptides, were able to bind bacterial cells, and had weak antibacterial effect, while biding of cytokines to bacterial cells had no effect on the bacterial attachment to mammal cells. In conclusion, it is suggested that some cytokines binds to bacteria causing to modulate the immune responses
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