2012 Fiscal Year Final Research Report
NETWORK ANALYSIS AMONG HARD TISSUE CELLS USING MULTI-PHOTON MICROSCOPE
| Project/Area Number |
22659335
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
WAKAMORI Minoru 東北大学, 大学院・歯学研究科, 教授 (50222401)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAI Jyunichi 埼玉大学, 脳科学癒合研究センター, 教授 (80237198)
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| Project Period (FY) |
2010 – 2012
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| Keywords | カルシウム / 機械刺激 / 細胞内 |
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| Research Abstract |
Osteoblasts and bone cells detect mechanical stimuli, and it is thought that their networks share information. The final goal of this project is to establish the method to analyze the network function among the cells by measuring intracellular Ca^<2+> concentration as an index. Ca^<2+> influx was observed in the osteoblast-like cells after extension. Moreover, Ca^<2+> fluorescent proteins worked like Ca^<2+> indicator fura-2.
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[Journal Article] Development of Purkinje cell degeneration in a knockin mouse model reveals lysosomal involvement in the pathogenesis of SCA62012
Author(s)
Unno T, Wakamori M, Koike M, Uchiyama Y, Ishikawa K, Kubota H, Yoshida T, Sasakawa H, Peters C, Mizusawa H, Watase K
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Journal Title
Proc Natl Acad Sci USA
Volume: 109
Pages: 17693-17698
DOI
Peer Reviewed
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[Journal Article] Rab3-interacting moleculer isoforms lacking the Rab3-binding domain induce long lasting currents but blockneurotransmitter vesicle anchoring in voltage-dependent P/Q-type Ca^<2+> channels2010
Author(s)
Uriu Y, Kiyonaka S, Miki T, Yagi M, Akiyama S, Mori E, Nakao A, Beedle AM, Campbell KP, Wakamori M, Mori Y
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Journal Title
J Biol Chem
Volume: 285
Pages: 21750-21767
DOI
Peer Reviewed
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[Journal Article] A missense mutation of the gene encoding voltage-dependent sodium channel (Nav1.1) confers susceptibility to febrile seizures in rats2010
Author(s)
Mashimo T, Ohmori I, Ouchida M, Ohno Y, Tsurumi T, Miki T, Wakamori M, Ishihara S, Yoshida T, Takizawa A, Kato M, Hirabayashi M, Sasa M, Mori Y, Serikawa T
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Journal Title
J Neurosci
Volume: 30
Pages: 5744-5753
DOI
Peer Reviewed
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