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2012 Fiscal Year Final Research Report

Development of radiolucent biodegradable material for sinus floor bone augmentation

Research Project

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Project/Area Number 22659355
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Dental engineering/Regenerative dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KASUGAI Shohei  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (70161049)

Project Period (FY) 2010 – 2012
Keywords骨 / 再生 / 上顎洞 / インプラント
Research Abstract

The purpose of the present study was to develop a material, with which we can observe new bone formation in maxillary sinus bone augmentation. Bony window at the buccal side of posterior maxillawas opened and maxillary sinus membrane was elevated. The bio-resorbable plate (fixorb) was placedunder the sinus membrane and fixed to the bone close to the bony window. Six months after the surgerybone formation was radiologically observed. We radiologically examined 19 implants at 13 sites of 10patients, average age 62.2 years old, who received sinus lift without graft material. In all cases bone wasformed around the implants and sinusitis was not observed. Bone is formed when space is produced onthe bone surface. Thus, we developed a new device, with which we elevated the periosteum, producingnew bone on the head of the rabbit. Furthermore, when we completely covered this device with a siliconmembrane, all the space was filled with new bone. We named this new method "expansible GBR".

  • Research Products

    (43 results)

All 2013 2012 2011 2010 Other

All Journal Article (11 results) Presentation (30 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Exploitation of a novel polysaccharide nanogel cross-linkingmembrane for guided bone regeneration(GBR).2012

    • Author(s)
      Miyahara T, Nyan M, Shimoda A,Yamamoto Y, Kuroda S, Shiota M,Akiyoshi K, Kasugai S.
    • Journal Title

      Journal of Tissue Engineering andRegenerative Medicine

      Volume: 6(8) Pages: 666-72

  • [Journal Article] Evaluation of biomimeticscaffold of gelatin-hydroxyapatite crosslinkas a novel scaffold for tissue engineering:Biocompatibility evaluation with humanPDL Fibroblasts, human mesenchymalstromal cells, and primary bone cells.2012

    • Author(s)
      Rungsiyanont S, Dhanesuan N, SwasdisonS, Kasugai S.
    • Journal Title

      Journal of Biomaterials Applications

      Volume: 27(1) Pages: 47-54

  • [Journal Article] A novelosteogenesis technique: The expansibleguided bone regeneration.2012

    • Author(s)
      Zakaria O, Madi M, Kasugai S.
    • Journal Title

      Journal of TissueEngineering:2041731412441194

  • [Journal Article] Evaluation of a biodegradable novel periosteal distractor.2012

    • Author(s)
      Zakaria O, Kon K, Kasugai S.
    • Journal Title

      Journal of Biomedical and MaterialResearch Part B - Applied Biomaterials

      Volume: 100(3) Pages: 882-9

  • [Journal Article] Inducedosteogenesis using a new periostealdistractor.2012

    • Author(s)
      Zakaria O, Madi M, Kasugai S.
    • Journal Title

      Journal of Oral MaxillofacialSurgery

      Volume: 70(3) Pages: 225-34

  • [Journal Article] Evaluation of the osteoconductivity of A- tricalcium phosphate, B -tricalcium phosphate, and hydroxyapatite combined with or without simvastatin in rat calvarial defect.2011

    • Author(s)
      Rojbani H, Nyan M, Ohya K, Kasugai S.
    • Journal Title

      Journal of Biomedical Materials Research: Part B - Applied Biomaterials

      Volume: 98(4) Pages: 488-98

  • [Journal Article] Implantation of green tea catechinA-tricalcium phosphate combinationenhances bone repair in rat skull defects.2011

    • Author(s)
      Rodriguez R, Kondo H, Nyan M, Hao J,Miyahara T, Ohya K, Kasugai S.
    • Journal Title

      Journal of Biomedical Materials Research:Part B - Applied Biomaterials

      Volume: 98B(2) Pages: 263-71

  • [Journal Article] Development of a new barrier membrane for guided bone regeneration: an in vitro and in vivo study.2011

    • Author(s)
      Noritake K, Kuroda S, Nyan M, Ohya K. Tabata Y, Kasugai S.
    • Journal Title

      Journal of Oral Tissue Engineering

      Volume: 9(2) Pages: 53-63

  • [Journal Article] Molecular and tissue responses in the healing of rat calvarial defects after local application of simvastatin combined with alpha tricalcium phosphate.2010

    • Author(s)
      Nyan M, Miyahara T, Noritake K, Hao J, Rodriguez R, Kuroda S, Kasugai S.
    • Journal Title

      Journal of Biomedical Materials Research Part B; Applied Biomaterials

      Volume: 93(1) Pages: 65-73

  • [Journal Article] Accelerated and enhanced bone formation on novel simvastatin-loaded porous titanium oxide surfaces.

    • Author(s)
      Nyan M, Hao J, Miyahara T, Noritake K, Rodriguez R, Kasugai S.
    • Journal Title

      Clinnical Implant Dentistry and Related Research

      Volume: (in press)

  • [Journal Article] Feasibility ofalpha tricalcium phosphate for vertical boneaugmentation.

    • Author(s)
      Nyan M, Miyahara T, Noritake K, Hao J,Rodriguez R, Kasugai S.
    • Journal Title

      Journal of Investigative andClinical Dentirty

      Volume: (in press)

  • [Presentation] New strategy for bone augmentation: Providing space and respecting endogenous healing potential.2013

    • Author(s)
      Kasugai S.
    • Organizer
      The 3rd Research Week-International Symposium of Collage of Oral Medicine
    • Place of Presentation
      Taipei Medical University, Taipei,Taiwang
    • Year and Date
      20130513-19
  • [Presentation] New strategy for effective, simple, less invasive and less costly bone augmentation.2013

    • Author(s)
      Kasugai S.
    • Organizer
      The 54th Congress of the Korean Association of Oral and Maxillofacial Surgeons.
    • Place of Presentation
      Hotel Inter-Burgo EXCO, Daegu, Korea
    • Year and Date
      20130425-27
  • [Presentation] How to augment boneeffectively, safely and less costly.2012

    • Author(s)
      Kasugai S.
    • Organizer
      BangkokImplant Sympoium 2012
    • Place of Presentation
      Pullman Hotel, Bangkok, Thailand
    • Year and Date
      20121128-30
  • [Presentation] Clinical outcome of sinus boneaugmentation without graft: radiologicalanalysis.2012

    • Author(s)
      Kusumoto Y, Kon K, Munakata M,Nakamura T, Tachikawa N, Shiota M,Kasugai S.
    • Organizer
      European Association for Osseointegration 21th Annual ScientificMeeting
    • Place of Presentation
      Bella Center,Copenhagen, Denmark
    • Year and Date
      20121010-13
  • [Presentation] A novelguided bone regeneration technique.2012

    • Author(s)
      Zakaria O, Madi M, Kasugai S.
    • Organizer
      European Association for Osseointegration 21th Annual Scientific Meeting
    • Place of Presentation
      Bella Center, Copenhagen,Denmark
    • Year and Date
      20121010-13
  • [Presentation] ラテラルアプローチによる上顎洞底挙上術同時インプラント埋入をおこなった症例における合併症.2012

    • Author(s)
      山本愛、宗像源博、松浦毅士、立川敬子、春日井昇平.
    • Organizer
      第42回日本口腔インプラント学会学術大会
    • Place of Presentation
      大阪国際会議場大阪
    • Year and Date
      20120921-23
  • [Presentation] サイナスリフト後に上顎洞アスペルギウス症を生じた1症例.2012

    • Author(s)
      作山葵、宗像源博、立川敬子、荻野幸治、春日井昇平.
    • Organizer
      第42回日本口腔インプラント学会学術大会
    • Place of Presentation
      大阪国際会議場大阪
    • Year and Date
      20120921-23
  • [Presentation] 骨補填材を併用しない上顎洞粘膜挙上・同時埋入のX線的検討.2012

    • Author(s)
      楠本雄生、今一裕、立川敬子、宗像源博、春日井昇平.
    • Organizer
      第42回日本口腔インプラント学会学術大会
    • Place of Presentation
      大阪国際会議場大阪
    • Year and Date
      20120921-23
  • [Presentation] 上顎洞底挙上術を併用したインプラント治療の予後.2012

    • Author(s)
      鶴見和久、宗像源博、湯川健、松浦毅士、春日井昇平.
    • Organizer
      第42回日本口腔インプラント学会学術大会2
    • Place of Presentation
      大阪国際会議場大阪
    • Year and Date
      20120921-23
  • [Presentation] New approach to boneregeneration: Respecting endogenous keyplayers and providing space for regeneration.2012

    • Author(s)
      Kasugai S.
    • Organizer
      International Congress of Oralimplantologists (ICOI), World Congress
    • Place of Presentation
      World Center Marriot Hotel,Orland, Florida, USA
    • Year and Date
      20120920-25
  • [Presentation] Novel strategy for boneaugmentation: Respecting "mother nature".2012

    • Author(s)
      Kasugai S.
    • Organizer
      The 11th Stomatology Confernce of WestChina
    • Place of Presentation
      Chengdu Convention Center, Chengdu (成都) China.
    • Year and Date
      20120420-23
  • [Presentation] ポリ乳酸デバイスをスペースメーキングに用いた移植材を使用しない上顎洞挙上術の臨床検討.2012

    • Author(s)
      宗像源博、立川敬子、能村嘉一、湯川健、春日井昇平.
    • Organizer
      第42回日本口腔インプラント学会学術大会
    • Place of Presentation
      大阪国際会議場大阪
    • Year and Date
      20120321-23
  • [Presentation] ポリ乳酸メッシュプレートを用いた移植材を併用しない上顎洞底挙上術の検討.2012

    • Author(s)
      宗像源博,立川敬子,能村嘉一,柏森高,春日井昇平.
    • Organizer
      第30回日本口腔インプラント学会関東甲信越支部学術大会
    • Place of Presentation
      京王プラザホテル新宿東京.
    • Year and Date
      20120211-12
  • [Presentation] 上顎洞底挙上術に用いたβ‐TCPの経時的体積変化のX線CT画像による検討.2012

    • Author(s)
      佐藤成実,宗像源博,立川敬子,岡田常次,春日井昇平.
    • Organizer
      第30回日本口腔インプラント学会関東甲信越支部学術大会京王プラザホテル新宿
    • Place of Presentation
      東京
    • Year and Date
      20120211-12
  • [Presentation] 上顎洞底挙上術を併用したインプラント治療の予後に関する臨床的検討.日本口腔インプラント学会2012

    • Author(s)
      山本愛、宗像源博、湯川健、立川敬子、春日井昇平.
    • Organizer
      第32回関東・甲信越支部学術大会
    • Place of Presentation
      京王プラザホテル東京
    • Year and Date
      20120210-11
  • [Presentation] New approach to boneaugmentation: Respecting endogenous keyplayers and providing space for regeneration.2012

    • Author(s)
      Kasugai S.
    • Organizer
      The 15th ICOI Asia Pacific Section Congress
    • Place of Presentation
      Intercontinental Hotel,Ho Chi Minh City, Vietnuam
    • Year and Date
      2012-06-23
  • [Presentation] Respecting endogenous keyplayers and providing space for boneaugmentation.2012

    • Author(s)
      Kasugai S.
    • Organizer
      The 10th Anniversary of the Korean Academy of Dental Sciences
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2012-02-26
  • [Presentation] アパタイトを用いたサイナスリフトクレスタルアプローチ法での挙上部の形態的安定性について.2012

    • Author(s)
      山本麻衣子、塩田真、今一裕、宗像源博、淵上慧、春日井昇平.
    • Organizer
      第2回バイオインテグレーション学会
    • Place of Presentation
      東京医科歯科大学東京
    • Year and Date
      2012-01-29
  • [Presentation] 後上歯槽動脈の欠損形態別分布の検証.2011

    • Author(s)
      渡邉武、塩田真,山本麻衣子、高尚、春日井昇平
    • Organizer
      日本口腔インプラント学会第41回学術大会
    • Place of Presentation
      名古屋国際会議場名古屋
    • Year and Date
      20110916-18
  • [Presentation] Key for bone augmentation: Making regenerative space and encouraging endogenous key players.2011

    • Author(s)
      Kasugai S.
    • Organizer
      Internation Society of Blood-derived Biomaterials (ISBB) Taipei Workshop
    • Place of Presentation
      Yang-Ming University, Taipei, Taiwang
    • Year and Date
      20110707-08
  • [Presentation] Keys for bone augmentation: Respecting endogenous key players and space for regeneration.2011

    • Author(s)
      Kasugai S.
    • Organizer
      Korean Association of Dental Sciences
    • Place of Presentation
      Yonsei University, Seoul, Korea
    • Year and Date
      2011-11-24
  • [Presentation] Bone augmentation in dentalimplant treatment: What is really requiredfor bone augmentation?2011

    • Author(s)
      Kasugai S.
    • Organizer
      Korean Acaddemyof Periodontology
    • Place of Presentation
      KyongpookNational University, Daegu, Korea
    • Year and Date
      2011-05-21
  • [Presentation] 骨造成に必要なものシンポジウム2011

    • Author(s)
      春日井昇平.
    • Organizer
      第65回口腔科学会学術大会
    • Place of Presentation
      タワーホール船堀東京
    • Year and Date
      2011-04-21
  • [Presentation] 歯科領域で使用する骨補填材.2011

    • Author(s)
      春日井昇平.
    • Organizer
      第1回バイオインテグレーション学会
    • Place of Presentation
      東京医科歯科大学MDタワー大講堂東京
    • Year and Date
      2011-01-24
  • [Presentation] 骨欠損を伴うインプラント治療の現状:骨造成に必要なものは何か?2010

    • Author(s)
      春日井昇平.
    • Organizer
      Dentistry, Quo Vadis?
    • Place of Presentation
      野口記念会館東京
    • Year and Date
      20101204-05
  • [Presentation] Challenge to treat atrophiedposterior maxilla: Are there evidences tosupport your decision?2010

    • Author(s)
      Kasugai S.
    • Organizer
      Bagkok Implant Syposium
    • Place of Presentation
      Pullman BagkokKing Power & Theatre Bagkok Thailand
    • Year and Date
      20101130-1203
  • [Presentation] 上顎洞外側壁における後上歯槽動脈の分布2010

    • Author(s)
      渡邉武、塩田真、春日井昇平.
    • Organizer
      第40回日本口腔インプラント学会学術大会
    • Place of Presentation
      札幌コンベンションセンターおよび札幌市産業振興センター、札幌
    • Year and Date
      20100917-19
  • [Presentation] β-TCPを用いた上顎洞挙上術の経時的変化の観察歯科用コーンビームCTによる分析.2010

    • Author(s)
      岡田常司、宗像源博、立川敬子、春日井昇平.
    • Organizer
      第40回日本口腔インプラント学会学術大会
    • Place of Presentation
      札幌コンベンションセンターおよび札幌市産業振興センター、札幌
    • Year and Date
      20100917-19
  • [Presentation] Evaluation ofa new biodegradable periosteal distractor.2010

    • Author(s)
      Zakaria O, Kon K, Kasugai S.
    • Organizer
      General Session (88th) and Exhibition ofInternational Association for Dental Research
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      20100714-17
  • [Presentation] What we really need for boneaugmentation?2010

    • Author(s)
      Kasugai S.
    • Organizer
      17th Alexandria Internationl Dental Cogress
    • Place of Presentation
      HiltonAlexandria Green Plaza, Alexandria, Egypt
    • Year and Date
      2010-11-24
  • [Patent(Industrial Property Rights)] 骨造成器具2012

    • Inventor(s)
      春日井昇平、オサマザカリア
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学
    • Industrial Property Number
      発明、PCT/JP2012/073229
    • Filing Date
      2012-09-11
    • Overseas
  • [Patent(Industrial Property Rights)] 骨造成器具2011

    • Inventor(s)
      春日井昇平、オサマザカリア
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学
    • Industrial Property Number
      発明、2011-198355
    • Filing Date
      2011-09-12

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Published: 2014-08-29   Modified: 2014-09-05  

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