2012 Fiscal Year Final Research Report
Challenging of new therapeutic modalities for pain management with narcotic pro-drug.
| Project/Area Number |
22659362
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
MASAKI Eiji 東北大学, 大学院・歯学研究科, 教授 (40221577)
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| Co-Investigator(Kenkyū-buntansha) |
MATOBA Atsuko (青井 あつ子) 東北大学, 大学院・歯学研究科, 助教 (70547257)
KURIHARA Jun 東北大学, 大学院・歯学研究科, 教授 (10508899)
YASUI Yutaka 東京慈恵会医科大学, 医学部, 助教 (80459651)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 麻薬 / プロドラッグ / ナノバブル / 遺伝子導入 / 鎮痛薬 |
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| Research Abstract |
The development of narcotic pro-drugs has been tried intensively. However, we have not yet succeeded to produce the pro-drugs. Because the combination between substrate protein and narcotics could not be matched well, the pro-drugs would not been produced. IT administration of esmolol and minocycline resulted in antinociceptive effects of short duration in a postoperative pain rat model. Moreover, induction of the gene for pain modulating factor, GDNF revealed antinociceptive effects.
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