2011 Fiscal Year Final Research Report
Development of study model and medical treatment procedure for the FGFR2-related craniosynostosis syndromes
| Project/Area Number |
22659363
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
MORI Shiro 東北大学, 病院, 講師 (80230069)
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| Co-Investigator(Renkei-kenkyūsha) |
KODAMA Tetsuya 東北大学, 医工学研究科, 教授 (40271986)
ONO Masao 東北大学, 医学系研究科, 教授 (20302218)
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| Project Period (FY) |
2010 – 2011
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| Keywords | FGFR2 / 疾患モデル / 関節強直症 / ナノバブル / 超音波 / 分子導入 |
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| Research Abstract |
The aim of the present study is to develop a study model and medical treatment procedure for the FGFR2-related craniosynostosis syndromes. In the present study, a new recombinant congenic strain of mice, which is a model for the dysplasia of bone and cartilage, was successfully established, and the onset of the disease in the mice was significantly associated with the genetic locus of FGFR2. By using the animal model and gene delivery system to the tissue around bone using nanobubbles and ultrasound, it became to be possible to perform an experimental molecular therapy using the Ig-Fc fusion protein of FGFR2 against the study model for the FGFR-related dysplasia of bone and cartilage.
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Research Products
(32 results)
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[Journal Article] Enhancement of autophagy is a potential modality for tumors refractory to radiotherapy2011
Author(s)
Y Kuwahara, T Oikawa, Y Ochiai, M H Roudkenar, M Fukumoto, T Shimura, Y Ohtake, Y Ohkubo, S Mori, Y Uchiyama, M Fukumoto
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Journal Title
Cell Death Dis
Volume: 2
Pages: e177
DOI
Peer Reviewed
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[Journal Article] Evaluation of transfection efficiency in skeletal muscle using nano/microbubbles and ultrasound2010
Author(s)
Tetsuya Kodama, Atsuko Aoi, Yukiko Watabnabe, Sachiko Horie, Mizuho Kodama, Li Li, Rui Chen, Noriyoshi Teramoto, Hidehiro Morikawa, Shiro Mori, Manabu Fukumoto
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Journal Title
Ultrasound Med Biol
Volume: 36(7)
Pages: 1196-1205
Peer Reviewed
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[Journal Article] Evaluating the Role of Rheumatoid Factors for the Development of Rheumatoid Arthritis in a Mouse Model with a Newly Established ELISA System2010
Author(s)
Yuki Tanaka, Hiroaki Komori, Shiro Mori, Yoshiko Soga, Takahito Tsubaki, Miho Terada, Tatsuhiko Miyazaki, Takahiro Fujino, Satoshi Nakamura, Hiroyuki Kanno, Tatsuya Sawasaki, Yaeta Endo, Masato Nose
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Journal Title
Tohoku J Exp Med
Volume: 220(3)
Pages: 199-206
Peer Reviewed
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[Presentation] 頭頸部癌所属リンパ節転移の診断・治療に向けたリンパ節腫大マウスを用いたリンパ節転移モデルの開発2011
Author(s)
李麗, 森士朗, 柳下陽子, サックスニコラ, 堀江佐知子, 渡邊夕紀子, 高地崇, 李深偉, 宮下仁, 森川秀広, 阪本真弥, 小玉哲也
Organizer
第35回日本頭頸部癌学会
Place of Presentation
名古屋
Year and Date
20110609-10
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[Presentation] 頭頸部癌遺伝子治療に向けたナノバブルと超音波によるNIS 遺伝子導入と124I-PET イメージング2011
Author(s)
渡邊夕紀子, 士朗, 堀江佐知子, サックスニコラ, 李麗, 李深偉, 柳下陽子, 高地崇, 船木善仁, 菊池洋平, 山崎浩道, 石井慶造, 阪本真弥, 宮下仁, 小玉哲也
Organizer
第35回日本頭頸部癌学会
Place of Presentation
名古
Year and Date
20110609-10
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[Presentation] 口腔癌早期診断のためのナノバブルと高周波超音波を用いた画像診断法に関する組織学的検討2010
Author(s)
柳下陽子, 森士朗, 李麗, 渡邊夕紀子, 堀江佐知子, 冨田典子, 陳鋭, 高田陽子, 大木宏介, 宮下仁, 小玉瑞穂, 川村仁, 森川秀広, 小玉哲也
Organizer
第34回日本頭頸部癌学会
Place of Presentation
東京
Year and Date
20100610-11
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[Presentation] Longitudinal three-dimentional noninvasive imaging analysis and quantification of ant-tumor effects of TNF-alpha gene for small tumor2010
Author(s)
Sachiko Horie, Yukiko Watanabe, Yoko Yagishita, Nicolas Sax, Rui Chen, Li Li, Takanori Kojima, Hidehiro Morikawa, Maya Sakamoto, Masao Ono, Shiro Mori, Tetsuya Kodama
Organizer
2010 World Molecular Imaging Congress
Place of Presentation
Kyoto, Japan
Year and Date
20100000
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