2012 Fiscal Year Final Research Report
Profiling of microRNAs in mouse mandibular condylar cartilage during development
| Project/Area Number |
22659376
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TERAO Fumie 九州大学, 大学院・歯学研究院, 助教 (10510018)
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| Project Period (FY) |
2010 – 2012
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| Keywords | microRNA / 下顎頭軟骨 / 歯科矯正学 / 軟骨細胞分化 |
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| Research Abstract |
We focused on miR-200a by microarray analysis of developing mandibular condylar cartilage (MCC) in mouse. Transfection experiments of miR-200a inhibitor or mimic were performed and demonstrated that miR-200a contributes to chondrogenesis in developing MCC through the control of proliferation and differentiation in MCC cells
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[Journal Article] The primary site of the acrocephalic feature in Apert syndrome is a dwarf cranial base with accelerated chondrocytic differentiation due to aberrant activation of the FGFR2 signaling2011
Author(s)
Nagata M, GH.Nuckolls, X Wang, L Shum, Seki Y, Kawase T, Takahashi K, Nonaka K, Takahashi I, AA.Nomar, Suzuki K, SlavkinHC.
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Journal Title
Bone
Volume: 48
Pages: 847-856
Peer Reviewed
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[Journal Article] Involvement of PRIP, phospholipase C-related, but catalytically inactive protein, in bone formation2011
Author(s)
Tsutsumi K, Matsuda M, Kotani M, Mizokami A, Murakami A, Takahashi I, Terada Y, Kanematsu T, Fukami K, Takenawa T, Jimi E, Hirata M.
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Journal Title
J Biol Chem
Volume: 286(35)
Pages: 31032-42
Peer Reviewed
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