2012 Fiscal Year Final Research Report
Analysis of frequency specificity, oscillations and adaptation in a signaling pathway consisting of multiple signaling modules.
| Project/Area Number |
22680024
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SAWAI Satoshi 東京大学, 大学院・総合文化研究科, 准教授 (20500367)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 生体情報 / 振動 |
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| Research Abstract |
Adaptive and oscillatory response consisting of multiple time-scales was analyzed by taking an example from cAMP-induced cAMP relay-response in Dictyostelium. Based on quantitative live-cell imaging analysis, we found that the first peak can be considered as an output from a module that realizes fold-change detection. The prolonged response on the other hand depends on the absolute concentration of extracellular cAMP and appears to be dependent on F-actin mediated feedaback. We discussed the relationship between these observed properties and robustness of cell-cell signaling.
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