2013 Fiscal Year Final Research Report
Formation and regulation of excitatory synapses
| Project/Area Number |
22680029
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HAYASHI Takashi 東京大学, 医学(系)研究科(研究院), 助教 (80547472)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Keywords | シナプス形成 / グルタミン酸 / 受容体 / 翻訳後修飾 / 精神疾患 / 恒常的可塑性 / スパイン / １分子観察 |
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| Research Abstract |
Glutamate is the major excitatory neurotransmitter in the central nervous system. Through this program, we focused on the formation and the regulation of glutamatergic excitatory synapses. Our findings revealed that the localization and trafficking of ionotropic glutamate receptors are regulated by tyrosine phosphorylation and palmitoylation in excitatory synapses. In addition, we showed that RhoA-mediated signaling pathway regulates IL1RAPL1-dependent formation and stabilization of glutamatergic synapses. Mutations of IL1RAPL1 and some palmitoyl acyl transferases are associated with mental disorders, indicating the crucial role of these molecules in the proper formation and regulation of glutamatergic synapses.
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[Journal Article] Homeostatic scaling requires group I mGluR activation mediated by Homer1a2010
Author(s)
Hu J.H., Park J.M., Park S., Xiao B., Dehoff M.H., Kim S., Hayashi T., Schwarz M.K., Huganir R.L., Seeburg P.H., Linden D.J., Worley P.F.
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Journal Title
Neuron
Volume: 68
Pages: 1128-1142
DOI
Peer Reviewed
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