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2012 Fiscal Year Final Research Report

Smart nanofibers that control cell functions

Research Project

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Project/Area Number 22680042
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionNational Institute for Materials Science

Principal Investigator

EBARA Mitsuhiro  独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA研究者 (10452393)

Project Period (FY) 2010 – 2012
Keywordsナノ材料 / 細胞・組織 / 再生医学 / 生体材料
Research Abstract

We prepared smart nanofibers and demonstrate the ability to capture, encapsulate, and release cells or drugs by dynamically transforming the fibrous structure of the nanofibers into hydrogel-like structures by wrapping, swelling, and deswelling processes in response to alternations of external temperature.

  • Research Products

    (34 results)

All 2013 2012 2011 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (12 results) Book (9 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] A photo-induced nanoparticle separation in microchannels via pH-sensitive surface traps2013

    • Author(s)
      M. Ebara, J. M. Hoffman, A. S. Hoffman, P. S. Stayton, J. J. Lai
    • Journal Title

      Langmuir

      Volume: 29 Pages: 5388-5393

    • DOI

      DOI: 10.1021/la400347r

    • Peer Reviewed
  • [Journal Article] Shape-memory surface with dynamically tunable nano-geometry activated by body heat2012

    • Author(s)
      M. Ebara, K. Uto, N. Idota, J. M. Hoffman, T. Aoyagi
    • Journal Title

      Advanced Materials

      Volume: 24 Pages: 273-278

    • DOI

      DOI: 10.1002/adma.201102181

    • Peer Reviewed
  • [Journal Article] A smart nanofiber web that captures and release cells2012

    • Author(s)
      Y.-J. Kim, M. Ebara, T. Aoyagi
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 51 Pages: 10537-10541

    • DOI

      DOI:10.1002/anie.201204139

    • Peer Reviewed
  • [Journal Article] Photo-switchable control of pH-responsive actuators via pH jump reaction2012

    • Author(s)
      P. Techawanitchai, M. Ebara, N. Idota, T.-A. Asoh, A. Kikuchi, T. Aoyagi
    • Journal Title

      Soft Matter

      Volume: 8 Pages: 2844-2851

    • DOI

      DOI:10.1039/C2SM07277G

    • Peer Reviewed
  • [Journal Article] Light-induced spatial control of pH-jump reaction at smart gel interface2012

    • Author(s)
      P. Techawanitchai, M. Ebara, N. Idota, T. Aoyagi
    • Journal Title

      Colloids and Surfaces B: Biointerfaces

      Volume: 99 Pages: 53-59

    • DOI

      DOI:10.1016/j.colsurfb.2011.09.039

    • Peer Reviewed
  • [Journal Article] Fabrication of dual-responsive polymer functionalized silica nanoparticles via a simple thiol-ene click chemistry2012

    • Author(s)
      Y. Kotsuchibashi, M. Ebara, T. Aoyagi, R. Narain
    • Journal Title

      Polymer Chemistry

      Volume: 3 Pages: 2545-2550

    • DOI

      DOI:10.1039/C2PY20333B

    • Peer Reviewed
  • [Journal Article] A smart hydrogel-based time bomb triggers drug release mediated by pH-jump reaction2012

    • Author(s)
      P. Techawanitchai, N. Idota, K. Uto, M. Ebara , T. Aoyagi
    • Journal Title

      Science and Technology of Advanced Materials

      Volume: 13

    • DOI

      DOI:10.1088/1468-6996/13/6/064202

    • Peer Reviewed
  • [Journal Article] Temperature-responsive electrospun nanofibers for "on-off" controlled dextran release2012

    • Author(s)
      Y.-J. Kim, M. Ebara, T. Aoyagi
    • Journal Title

      Science and Technology of Advanced Materials

      Volume: 13

    • DOI

      DOI:0.1088/1468-6996/13/6/064203

    • Peer Reviewed
  • [Journal Article] Novel temperature-responsive polymer brushes with carbohydrate residues facilitate selective adhesion and collection of hepatocytes2012

    • Author(s)
      N. Idota, M. Ebara, Y. Kotsuchibashi, R. Narain, T. Aoyagi
    • Journal Title

      Science and Technology of Advanced Materials

      Volume: 13

    • DOI

      DOI:0.1088/1468-6996/13/6/064206

    • Peer Reviewed
  • [Journal Article] A Smart Hyperthermia Nanofiber with Switchable Drug Release for Inducing Cancer Apoptosis

    • Author(s)
      Y.-J. Kim, M. Ebara, T. Aoyagi
    • Journal Title

      Advanced Functional Materials, in press

    • Peer Reviewed
  • [Journal Article] Fabrication of FITC-doped silica nanoparticles and study of their ceullar uptake in the presence of lectins

    • Author(s)
      Y. Kotsuchibashi, Y. Zhang, M. Ahmed, M. Ebara, T. Aoyagi, R. Narain
    • Journal Title

      Journal of Biomedical Materials Research

      Volume: Part A

    • DOI

      DOI:10.1088/1468-6996/13/6/064207

    • Peer Reviewed
  • [Presentation] 自己発熱に応答して薬物を放出するハイパーサーミアナノファイバーの作製2013

    • Author(s)
      荏原充宏, 金榮鎭, 青柳隆夫
    • Organizer
      第62回高分子学会年次大会
    • Place of Presentation
      京都
    • Year and Date
      20130529-31
  • [Presentation] Smart Nanofiber Webs for "On-off" Release of Cells and Drugs2013

    • Author(s)
      M. Ebara, Y. Kim, T. Aoyagi
    • Organizer
      2013 Annual Meeting of the Society For Biomaterials
    • Place of Presentation
      Boston, USA
    • Year and Date
      20130410-13
  • [Presentation] "A Smart Hyperthermia Nanofiber with Controlled Drug Release for Improved Cancer Therapy2013

    • Author(s)
      Y. Kim, M. Ebara, T. Aoyagi
    • Organizer
      2nd International Conference on Biomaterials Science in Tsukuba
    • Place of Presentation
      Japan
    • Year and Date
      20130319-22
  • [Presentation] On-demand Encapsulation and Release of Cells using On-off Switchable Fibrous Hydrogels2013

    • Author(s)
      金榮鎭, 荏原充宏, 青柳隆夫
    • Organizer
      第24回高分子ゲル研究討論会
    • Place of Presentation
      東京
    • Year and Date
      20130116-17
  • [Presentation] Smart nanofibers for "on-off" switchable release of cell/drug2013

    • Author(s)
      Y. Kim, M. Ebara, T. Aoyagi
    • Organizer
      つくば医工連携フォーラム2013 医工連携のHub化~つくば
    • Place of Presentation
      つくば
    • Year and Date
      2013-01-29
  • [Presentation] 温度応答性ナノファイバーを用いた薬物の"On-Off" 放出制御2012

    • Author(s)
      金榮鎭, 荏原充宏, 青柳隆夫
    • Organizer
      日本バイオマテリアル学会シンポジウム2012
    • Place of Presentation
      仙台
    • Year and Date
      20121126-27
  • [Presentation] Smart Biomaterials Design for Nano-biotechnology2012

    • Author(s)
      T. Aoyagi, Y. Kim, M. Ebara
    • Organizer
      6th International Workshop on Advanced Materials Science
    • Place of Presentation
      Ha Long City, Vietnam
    • Year and Date
      20121030-1102
  • [Presentation] A New Class of Smart Fibrous-Hydrogel that Cell Capture and Release2012

    • Author(s)
      Y. Kim, M. Ebara, T. Aoyagi
    • Organizer
      7th International Symposium on Stimuli-Responsive Materials
    • Place of Presentation
      Santa Rosa, USA
    • Year and Date
      20121021-23
  • [Presentation] Thermo-crosslinkable and temperature-responsive fibrous hydrogel via electrospinning for "on-off" controlled dextran release2012

    • Author(s)
      Y. Kim, M. Ebara, T. Aoyagi
    • Place of Presentation
      ゲルワークショップイン名古屋
    • Year and Date
      20120921-22
  • [Presentation] 光架橋点を有するスマートナノファイバーの設計と細胞のキャッチ&リリース2012

    • Author(s)
      荏原充宏, 青柳隆夫
    • Organizer
      第61回高分子討論会
    • Place of Presentation
      名古屋
    • Year and Date
      20120919-21
  • [Presentation] Photo-crosslinkable and Thermo-Responsive Nanofiber Webs for 'On-Off' Switches of Cell Capture/Release2012

    • Author(s)
      Y. Kim, M. Ebara, T. Aoyagi
    • Organizer
      NanoBio Seattle2012
    • Place of Presentation
      Seattle, USA
    • Year and Date
      20120723-26
  • [Presentation] Design of photo-crosslinkable and thermo-responsive nanofiber mats for cell manipulations2012

    • Author(s)
      金榮鎭, 荏原充宏, 青柳隆夫
    • Organizer
      第61回高分子学会年次大会
    • Place of Presentation
      横浜
    • Year and Date
      20120529-31
  • [Book] 生分解性高分子' 再生医療叢書2 組織工学2013

    • Author(s)
      荏原充宏, 宇都甲一郎, 青柳隆夫
    • Total Pages
      1-24
    • Publisher
      朝倉書店
  • [Book] 免疫反応を制御可能な未来型バイオマテリアルの設計―Immunobioengineering'― Drug Delivery System2013

    • Author(s)
      荏原充宏, 齋藤充弘
    • Total Pages
      135-148
    • Publisher
      日本DDS学会
  • [Book] 基材の構造力学的性質による細胞機能の制御' 特集 細胞接着の制御 生体の科学2013

    • Author(s)
      荏原充宏, 宇都甲一郎, 青柳隆夫
    • Total Pages
      194-198
  • [Book] Chapter 10 Nanotechnology in Drug Delivery Systems" Manipulation of Nanoscale Materials2012

    • Author(s)
      Kohsaku Kawakami and Mitsuhiro Ebara
    • Total Pages
      242-258
  • [Book] スマートバイオマテリアルの応用'― ケミカルエンジニヤリング2012

    • Author(s)
      荏原充宏, 青柳隆夫
    • Total Pages
      31-36
    • Publisher
      化学工業社
  • [Book] "Supramolecular approaches for drug development" Current Medicinal Chemistry2012

    • Author(s)
      Kohsaku Kawakami, Mitsuhiro Ebara, Hironori Izawa, Noelia M. Sanchez-Ballester, Jonathan P. Hill, and Katsuhiko Ariga
    • Total Pages
      2388-2398
  • [Book] スマートゲル表面' 特集スマートゲルの最新動向― 機能材料2012

    • Author(s)
      荏原充宏
    • Total Pages
      6-12
    • Publisher
      シーエムシー出版
  • [Book] 形状記憶インターフェイスを用いた細胞運命の時間・空間操作' Colloid & Interface Communication2011

    • Author(s)
      荏原充宏
    • Total Pages
      23-24
    • Publisher
      日本化学会
  • [Book] Toward the generation of patient-specific patches for cardiac repair." Stem Cell Reviews and Reports

    • Author(s)
      Giancarlo Forte, Stefania Pagliari, Francesca Pagliari, Mitsuhiro Ebara, Paolo Di Nardo, Takao Aoyagi
  • [Remarks]

    • URL

      http://www.nims.go.jp/bmc/group/smartbiomaterials/

  • [Patent(Industrial Property Rights)] アジド基又はアルキン基を有するイソプロピルアクリルアミド誘導体およびその重合体2011

    • Inventor(s)
      ジョンホフマン、青柳隆夫、荏原充宏
    • Industrial Property Rights Holder
      物質材料研究機構
    • Industrial Property Number
      特願2011-067969
    • Filing Date
      2011-03-25

URL: 

Published: 2014-08-29  

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