The novel nutrient sensing mechanism and development of disease prophylaxis

2012 Fiscal Year Final Research Report

• Project/Area Number: 22680053
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: The University of Tokushima
• Principal Investigator: YAMOMOTO Hironori 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (60314861)
• Project Period (FY): 2010 – 2012
• Keywords: 健康と食生活

Research Abstract

In this study, we worked on the development of disease prevention methods and the discovery of novel nutrition sensor. As a result, thyroid hormone receptors and sterol regulatory binding proteins SREBPs play animportant role as the transcription factor for the transcriptional regulation of CYP27B1 gene which is vitamin D metabolism enzyme. Further, the development of ectopic calcification in the premature aging mouse models having a phosphorus metabolic abnormalities,revealed the possibility of stanniocalcin 2 contributes as a defense factor.

Research Products

• [Journal Article] Takeda E. Role of serine 249 of ezrin in the regulation of sodium-dependent phosphate transporter NaPi-IIa activity in renal proximal tubular cells. (2013)
  • Author(s): Yamada F, Horie D, Nakamura A, Tanimura A, Yamamoto H, Segawa H, Ito M, Miyamoto K, Taketani Y
  • Journal Title: J Med Invest Volume: 60(1-2) Pages: 27-34
  • URL: http://dx.doi.org/10.2152/jmi.60.27
  • Peer Reviewed
• [Journal Article] Thyroid hormones decrease plasma 1α,25-dihydroxyvitamin D levels through transcriptional repression of the renal 25-hydroxyvitamin D3 1α-hydroxylase gene (CYP27B1) (2013)
  • Author(s): Kozai M, Yamamoto H, Ishiguro M, Harada N, Masuda M, Kagawa T, Takei Y, Otani A, Nakahashi O, Ikeda S, Taketani Y, Takeyama K, Kato S, Takeda E
  • Journal Title: Endocrinology Volume: 154(2) Pages: 609-622
  • DOI: DOI:10.1210/en.2012-1647
  • Peer Reviewed
• [Journal Article] Up-regulation of stanniocalcin 1 expression by 1,25-dihydroxy vitamin D(3) and parathyroid hormone in renal proximal tubular cells (2012)
  • Author(s): Hung NT, Yamamoto H, Takei Y, Masuda M, Otani A, Kozai M, Ikeda S, Nakahashi O, Tanaka S, Taketani Y, Takeda E
  • Journal Title: J Clin Biochem Nutr Volume: 50(3) Pages: 227-233
  • DOI: DOI:10.3164/jcbn.11-99
  • Peer Reviewed
• [Journal Article] Stanniocalcin 2 is associated with ectopic calcification in α-klotho mutant mice and inhibits hyperphosphatemia-induced calcification in aortic vascular smooth muscle cells (2012)
  • Author(s): Takei Y, Yamamoto H, Sato T, Otani A, Kozai M, Masuda M, Taketani Y, Muto-Sato K, Lanske B, Takeda E
  • Journal Title: Bone. Volume: 50(4) Pages: 998-1005
  • DOI: DOI:10.1016/j.bone.2012.01.006
  • Peer Reviewed
• [Journal Article] Natto and viscous vegetables in a Japanese-style breakfast improved insulin sensitivity, lipid metabolism and oxidative stress in overweight subjects with impaired glucose tolerance (2012)
  • Author(s): Taniguchi-Fukatsu A, Yamanaka-Okumura H, Naniwa-Kuroki Y, Nishida Y, Yamamoto H, Taketani Y, Takeda E
  • Journal Title: Br J Nutr Volume: 107(8) Pages: 1184-1191
  • DOI: DOI:10.1017/S0007114511004156
  • Peer Reviewed
• [Journal Article] Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol-enriched diet (2012)
  • Author(s): Uebanso T, Taketani Y, Yamamoto H, Amo K, Tanaka S, Arai H, Takei Y, Masuda M, Yamanaka-Okumura H, Takeda E
  • Journal Title: J Nutr Biochem Volume: 23(7) Pages: 785-790
  • Peer Reviewed
• [Journal Article] High phosphate diet reduces atherosclerosis formation in apolipoprotein E-deficient mice (2011)
  • Author(s): Shiota A, Taketani Y, Maekawa Y, Yasutomo K, Sata M, Sakai T, Mizuno R, Isshiki M, Yamamoto H, Takeda E
  • Journal Title: J Clin Biochem Nutr Volume: 49(2) Pages: 109-114
  • DOI: DOI:10.3164/jcbn.10-150
  • Peer Reviewed
• [Journal Article] Paradoxical regulation of human FGF21 by both fasting and feeding signals: is FGF21 a nutritional adaptation factor? (2011)
  • Author(s): Uebanso T, Taketani Y, Yamamoto H, Amo K, Ominami H, Arai H, Takei Y, Masuda M, Tanimura A, Harada N, Yamanaka-Okumura H, Takeda E
  • Journal Title: PLoS One Volume: 6(8) Pages: e22976.
  • DOI: DOI:10.1016/j.jnutbio.2011.03.023
  • Peer Reviewed
• [Journal Article] Effects of xylitol on metabolic parameters and visceral fat accumulati (2011)
  • Author(s): Amo K, Arai H, Uebanso T, Fukaya M, Koganei M, Sasaki H, Yamamoto H, Taketani Y, Takeda E.
  • Journal Title: J Clin Biochem Nutr Volume: 49(1) Pages: 1-7
  • DOI: DOI:10.3164/jcbn.10-111
  • Peer Reviewed
• [Journal Article] Quercetin Prevents Unloading-Derived Disused Muscle Atrophy by Attenuating the Induction of Ubiquitin Ligases in Tail-Suspension Mice (2010)
  • Author(s): Mukai R, Nakao R, Yamamoto H, Nikawa T, Takeda E, Terao J
  • Journal Title: J Nat Prod Volume: 73(10) Pages: 1708-1710
  • DOI: DOI:10.1021/np100240y
  • Peer Reviewed
• [Journal Article] Regulation of renal sodium-dependent phosphate co-transporter genes (Npt2a and Npt2c) by all-trans-retinoic acid and its receptors (2010)
  • Author(s): Masuda M, Yamamoto H, Kozai M, Tanaka S, Ishiguro M, Takei Y, Nakahashi O, Ikeda S, Uebanso T, Taketani Y, Segawa H, Miyamoto K, Takeda E
  • Journal Title: Biochem J. Volume: 429(3) Pages: 583-592
  • DOI: DOI:10.1042/BJ20100484
  • Peer Reviewed
• [Presentation] Regional Up-regulation of 25-hydroxyvitamin D 1 alpha-hydroxylase (CYP27B1) Gene Is Associated with the Pathogenesis of Ectopic Calcification in the Alpha Klotho Mutant Mice (2012)
  • Author(s): Yamamoto H, Otani A, Yokoyama N, Onishi R, Yakei Y, Taketani Y, Miyamoto K, Takeda E
  • Organizer: 34th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Minneapolis convention center, (Minnesota, USA)
  • Year and Date: 20121012-15
• [Presentation] Induction of the Intact and C-terminal FGF23 Levels and Its Gene Expression in Lipopolysaccharide- Induced Acute Inflammation (2012)
  • Author(s): Ikeda S, Yamamoto H, Nakahashi O, Kozai M, Taketani Y, Takeda E
  • Organizer: 34th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Minneapolis convention center, (Minnesota, USA)
  • Year and Date: 20121012-15
• [Presentation] Dietary Phosphorus Restriction Up-regulates the Ileal Fibroblast Growth Factor 15 Gene Expression through the Vitamin D Receptor Activation (2012)
  • Author(s): Nakahashi O, Yamamoto H, Tanaka S, Kozai M, Taketani Y, Miyamoto K-I, Kato S, Takeda E
  • Organizer: 34th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Minneapolis convention center, (Minnesota, USA)
  • Year and Date: 20121012-15
• [Presentation] リン・カルシウムバランスが肝臓時計遺伝子および脂質代謝の日内リズムに与える影響 (2012)
  • Author(s): 山本浩範
  • Organizer: 第19回日本時間生物学会学術大会
  • Place of Presentation: 北海道大学、(北海道)
  • Year and Date: 20120915-16
• [Presentation] 生体リン・ビタミン D 代謝の概日リズムの分子機構の解明 (2012)
  • Author(s): 山本浩範、向原理恵、中橋乙起、池田翔子、香西美奈、竹谷豊、武田英二
  • Organizer: 第30回日本骨代謝学会学術集会
  • Place of Presentation: 京王プラザホテル、(東京都)
  • Year and Date: 20120719-21
• [Presentation] αKlotho-Fgf23 シグナル異常による 25-ヒドロキシビタミン D3-1α水酸化酵素(CYP27B1)発現亢進と異所性石灰化発症の分子機構の解明 (2012)
  • Author(s): 山本浩範、大谷彩子、横山望、香西美奈、池田翔子、竹谷豊、武田英二
  • Organizer: 第30回日本骨代謝学会学術集会
  • Place of Presentation: 京王プラザホテル、(東京都)
  • Year and Date: 20120719-21
• [Presentation] リン・ビタミン D 代謝の概日リズムの解析 (2012)
  • Author(s): 向原理恵、山本浩範、中橋乙起、池田翔子、香西美奈、竹谷豊、武田英二
  • Organizer: 日本ビタミン学会第64回大会
  • Place of Presentation: 長良川国際会議場、(岐阜県)
  • Year and Date: 20120622-23
• [Presentation] レチノイン酸は IIb 型リン酸トランスポーターNpt2b発現を抑制し小腸リン吸収を低下させる (2012)
  • Author(s): 山本浩範、増田真志、田中更沙、香西美奈、竹谷豊、宮本賢一、武田英二
  • Organizer: 第66回日本栄養・食糧学会大会
  • Place of Presentation: 東北大学、(宮城県)
  • Year and Date: 20120518-20